LTA4H
Leukotriene A-4 hydrolase
Protein Summary
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
- ENST00000228740
- ENSP00000228740
- ENSG00000111144
- ENST00000413268
- ENSP00000395051
- ENST00000552789
- ENSP00000449958
- LTA4
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.91 | ||
drug | 0.85 | ||
molecular function | 0.79 | ||
tissue | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 273.59 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 446 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 273.59 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 446 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 447
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3