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Tbio
LTA
Lymphotoxin-alpha

Protein Summary
Description
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000412851
  • ENSP00000412555
  • ENSG00000230279
  • ENST00000418386
  • ENSP00000413450
  • ENSG00000226979
  • ENST00000426845
  • ENSP00000402413
  • ENST00000436519
  • ENSP00000395976
  • ENSG00000231408
  • ENST00000454550
  • ENSP00000416509
  • ENST00000454783
  • ENSP00000403495

Symbol
  • TNFB
  • TNFSF1
  • LT
  • TNFB
  • TNFSF1
  • TNLG1E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.94
disease
0.94
phenotype
0.9
biological process
0.87
cell type or tissue
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.83   (req: < 5)
Gene RIFs: 221   (req: <= 3)
Antibodies: 701   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.83   (req: >= 5)
Gene RIFs: 221   (req: > 3)
Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0