Tbio LTA Lymphotoxin-alpha

Protein Summary

Description

Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• P01374
• Q8N4C3
• Q9UKS8
• LT-alpha

Gene Name

• LTA

Ensembl ID

• ENST00000412851
• ENSP00000412555
• ENSG00000230279
• ENST00000418386
• ENSP00000413450
• ENSG00000226979
• ENST00000426845
• ENSP00000402413
• ENST00000436519
• ENSP00000395976
• ENSG00000231408
• ENST00000454550
• ENSP00000416509
• ENST00000454783
• ENSP00000403495

Symbol

• TNFB
• TNFSF1
• LT
• TNFB
• TNFSF1
• TNLG1E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.94
disease	0.94
phenotype	0.9
biological process	0.87
cell type or tissue	0.83

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Cytokine / Tumor Necrosis Factor Family Member / Lymphotoxin-alpha

DTO Classes

Protein / Signaling / Cytokine / Tumor Necrosis Factor Family Member / Lymphotoxin-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.83   (req: < 5)

Gene RIFs: 221   (req: <= 3)

Antibodies: 701   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 883.83   (req: >= 5)

Gene RIFs: 221   (req: > 3)

Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0