Protein Summary
Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo. The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
- ENST00000412851
- ENSP00000412555
- ENSG00000230279
- ENST00000418386
- ENSP00000413450
- ENSG00000226979
- ENST00000426845
- ENSP00000402413
- ENST00000436519
- ENSP00000395976
- ENSG00000231408
- ENST00000454550
- ENSP00000416509
- ENST00000454783
- ENSP00000403495
- TNFB
- TNFSF1
- LT
- TNFB
- TNFSF1
- TNLG1E
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.94 | ||
disease | 0.94 | ||
phenotype | 0.9 | ||
biological process | 0.87 | ||
cell type or tissue | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 802.12 (req: < 5)
Gene RIFs: 221 (req: <= 3)
Antibodies: 701 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 802.12 (req: >= 5)
Gene RIFs: 221 (req: > 3)
Antibodies: 701 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (207)
ANKRD40
Novelty: 1.06633958
p_int: 0.956792251
p_ni: 0.043207749
Score: 0.282
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (53)
Reactome (5)
KEGG (7)
PathwayCommons (10)
WikiPathways (31)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
Reactome | TNFR2 non-canonical NF-kB pathway | ||||
Reactome | TNFs bind their physiological receptors | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway | ||||
TNFR2 non-canonical NF-kB pathway | ||||
TNFs bind their physiological receptors | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (3)
Components (2)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (339)
Items per page:
1 – 5 of 339
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
lymphocyte count | 3 | 5 | 7 | 98.6 | ||||||
lymphocyte count | 3 | 5 | 7 | 98.6 | ||||||
lymphocyte count | 3 | 5 | 7 | 98.6 | ||||||
1 | 9 | 0 | 2.3 | 98.1 | ||||||
1 | 9 | 0 | 2.3 | 98.1 | ||||||
Items per page:
1 – 5 of 339
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
lymphocyte count | 7 | 98.6 | |||||
lymphocyte count | 7 | 98.6 | |||||
lymphocyte count | 7 | 98.6 | |||||
0 | 2.3 | 98.1 | |||||
0 | 2.3 | 98.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lymphotoxin alpha | VGNC:11106 | 494185 | |||||
Macaque | lymphotoxin alpha | 715425 | ||||||
Mouse | MGI:104797 | 16992 | ||||||
Rat | RGD:3020 | 25008 | ||||||
Dog | lymphotoxin alpha | VGNC:42852 | 607183 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lymphotoxin alpha | |||||
Macaque | lymphotoxin alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | lymphotoxin alpha | |||||
Publication Statistics
PubMed Score 802.12
PubMed score by year
PubTator Score 695.85
PubTator score by year
Related Publications
Text Mined References (557)
GeneRif Annotations (221)
Items per page:
0 of 0
PMID | Year | Title |
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