Protein Summary
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
- ENST00000356396
- ENSP00000348762
- ENSG00000160285
- ENST00000397728
- ENSP00000380837
- ENST00000457828
- ENSP00000409191
- ENST00000522411
- ENSP00000429133
- OSC
- OSC
- HYPT14
- CTRCT44
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.83 | ||
small molecule perturbation | 0.8 | ||
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.76 | ||
gene perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.1 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.1 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 94
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (94)
Protein-Protein Interactions (118)
PNKD
Family: Enzyme
Novelty: 0.02456078
p_int: 0.999993192
p_ni: 0.000006805
p_wrong: 3e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ALOX5
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999918519
p_ni: 0.000081474
p_wrong: 7e-9
Data Source: BioPlex
TNFRSF10A
Novelty: 0.0003383
p_int: 0.999892211
p_ni: 0.000107735
p_wrong: 5.4e-8
Score: 0.153
Data Source: BioPlex,STRINGDB
LYPD4
Novelty: 0.00381728
p_int: 0.986234719
p_ni: 0.009819359
p_wrong: 0.003945922
Data Source: BioPlex
GATD1
Family: Enzyme
Novelty: 0.40291197
p_int: 0.984286651
p_ni: 0.004821261
p_wrong: 0.010892088
Data Source: BioPlex
GML
Novelty: 0.04982168
p_int: 0.980959831
p_ni: 0.009792443
p_wrong: 0.009247726
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (26)
Reactome (6)
KEGG (2)
PathwayCommons (7)
UniProt (1)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Cholesterol biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Cholesterol biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 61.8 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 53.7 | |||||
1 | 1 | 0 | 1.2 | 52 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 39.4 | |||||
1 | 1 | 0 | 1.3 | 35 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 61.8 | |||||
monocyte percentage of leukocytes | 1 | 53.7 | |||||
0 | 1.2 | 52 | |||||
BMI-adjusted waist circumference | 2 | 39.4 | |||||
0 | 1.3 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lanosterol synthase | VGNC:14674 | 474058 | |||||
Macaque | lanosterol synthase | 709227 | ||||||
Mouse | MGI:1336155 | 16987 | ||||||
Rat | RGD:620955 | 81681 | ||||||
Dog | lanosterol synthase | VGNC:42851 | 491611 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lanosterol synthase | |||||
Macaque | lanosterol synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | lanosterol synthase | |||||
Publication Statistics
PubMed Score 128.10
PubMed score by year
PubTator Score 58.65
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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