Protein Summary
Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus. Through the production of lanosterol may regulate lens protein aggregation and increase transparency. The protein encoded by this gene catalyzes the conversion of (S)-2,3 oxidosqualene to lanosterol. The encoded protein is a member of the terpene cyclase/mutase family and catalyzes the first step in the biosynthesis of cholesterol, steroid hormones, and vitamin D. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Feb 2009]
- ENST00000356396
- ENSP00000348762
- ENSG00000160285
- ENST00000397728
- ENSP00000380837
- ENST00000457828
- ENSP00000409191
- ENST00000522411
- ENSP00000429133
- OSC
- OSC
- HYPT14
- CTRCT44
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
disease perturbation | 0.83 | ||
small molecule perturbation | 0.8 | ||
transcription factor perturbation | 0.8 | ||
histone modification site profile | 0.76 | ||
gene perturbation | 0.72 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.1 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 146 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 128.1 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 146 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 94
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (94)
Protein-Protein Interactions (118)
PNKD
Family: Enzyme
Novelty: 0.02456078
p_int: 0.999993192
p_ni: 0.000006805
p_wrong: 3e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
ALOX5
Family: Enzyme
Novelty: 0.00062988
p_int: 0.999918519
p_ni: 0.000081474
p_wrong: 7e-9
Data Source: BioPlex
TNFRSF10A
Novelty: 0.0003383
p_int: 0.999892211
p_ni: 0.000107735
p_wrong: 5.4e-8
Score: 0.153
Data Source: BioPlex,STRINGDB
LYPD4
Novelty: 0.00381728
p_int: 0.986234719
p_ni: 0.009819359
p_wrong: 0.003945922
Data Source: BioPlex
GATD1
Family: Enzyme
Novelty: 0.40291197
p_int: 0.984286651
p_ni: 0.004821261
p_wrong: 0.010892088
Data Source: BioPlex
GML
Novelty: 0.04982168
p_int: 0.980959831
p_ni: 0.009792443
p_wrong: 0.009247726
Score: 0.173
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (26)
Reactome (6)
KEGG (2)
PathwayCommons (7)
UniProt (1)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of gene expression by SREBF (SREBP) | ||||
Reactome | Cholesterol biosynthesis | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | Metabolism of steroids | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of gene expression by SREBF (SREBP) | ||||
Cholesterol biosynthesis | ||||
Metabolism | ||||
Metabolism of lipids | ||||
Metabolism of steroids | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (1)
Components (3)
Processes (4)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 2 | 2 | 61.8 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 53.7 | |||||
1 | 1 | 0 | 1.2 | 52 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 39.4 | |||||
1 | 1 | 0 | 1.3 | 35 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 2 | 61.8 | |||||
monocyte percentage of leukocytes | 1 | 53.7 | |||||
0 | 1.2 | 52 | |||||
BMI-adjusted waist circumference | 2 | 39.4 | |||||
0 | 1.3 | 35 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | lanosterol synthase | VGNC:14674 | 474058 | |||||
Macaque | lanosterol synthase | 709227 | ||||||
Mouse | MGI:1336155 | 16987 | ||||||
Rat | RGD:620955 | 81681 | ||||||
Dog | lanosterol synthase | VGNC:42851 | 491611 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | lanosterol synthase | |||||
Macaque | lanosterol synthase | |||||
Mouse | ||||||
Rat | ||||||
Dog | lanosterol synthase | |||||
Publication Statistics
PubMed Score 128.10
PubMed score by year
PubTator Score 58.65
PubTator score by year
Related Publications
Text Mined References (32)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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