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Tbio
LSR
Lipolysis-stimulated lipoprotein receptor

Protein Summary
Description
Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000347609
  • ENSP00000262627
  • ENSG00000105699
  • ENST00000354900
  • ENSP00000346976
  • ENST00000360798
  • ENSP00000354034
  • ENST00000361790
  • ENSP00000354575
  • ENST00000427250
  • ENSP00000394479
  • ENST00000602122
  • ENSP00000472569
  • ENST00000621372
  • ENSP00000480821

Symbol
  • LISCH
  • ILDR3
  • LISCH7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.75
transcription factor perturbation
0.74
transcription factor binding site profile
0.73
histone modification site profile
0.72
tissue
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.3   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 205.3   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (109)
STON2
Tbio
Novelty:  0.02098671
p_int:  0.999990119
p_ni:  0.000009878
p_wrong:  3e-9
Score:  0.157
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.999987547
p_ni:  0.000012453
Data Source:  BioPlex
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.99991047
p_ni:  0.00008953
Data Source:  BioPlex
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999754424
p_ni:  0.000245576
Data Source:  BioPlex
SMAD5
Tbio
Family:  TF
Novelty:  0.00405952
p_int:  0.999390886
p_ni:  0.00060373
p_wrong:  0.000005384
Score:  0.189
Data Source:  BioPlex,STRINGDB
REPS1
Tbio
Novelty:  0.08952347
p_int:  0.998510466
p_ni:  0.001489531
p_wrong:  3e-9
Score:  0.529
Data Source:  BioPlex,STRINGDB
LSMEM2
Tdark
Novelty:  43
p_int:  0.994275466
p_ni:  0.005724534
Data Source:  BioPlex
ITSN1
Tbio
Novelty:  0.01327346
p_int:  0.992653153
p_ni:  0.007346847
Data Source:  BioPlex
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.989580621
p_ni:  0.010419379
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.988640843
p_ni:  0.011359157
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
LDL clearance (R-HSA-8964038)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
LDL clearance
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Transport of small molecules
Reactome
VLDL clearance
Name
Explore in Pharos
Explore in Source
LDL clearance
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Transport of small molecules
VLDL clearance
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
HGNC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
3
93.3
red blood cell distribution width
4
5
7
92.3
reticulocyte count
7
3
7
92
reticulocyte measurement
3
2
3
83.3
mean corpuscular hemoglobin concentration
1
1
1
73.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
93.3
red blood cell distribution width
7
92.3
reticulocyte count
7
92
reticulocyte measurement
3
83.3
mean corpuscular hemoglobin concentration
1
73.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipolysis stimulated lipoprotein receptor
VGNC:2319
468834
Mouse
MGI:1927471
54135
Rat
RGD:69236
64355
Dog
lipolysis stimulated lipoprotein receptor
VGNC:42850
484581
Horse
lipolysis stimulated lipoprotein receptor
VGNC:19826
100059229
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipolysis stimulated lipoprotein receptor
Mouse
Rat
Dog
lipolysis stimulated lipoprotein receptor
Horse
lipolysis stimulated lipoprotein receptor
Publication Statistics
PubMed Score 205.30
PubMed score by year
PubTator Score 26.57
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title