Tbio LSR Lipolysis-stimulated lipoprotein receptor

Protein Summary

Description

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity).

Uniprot Accession IDs

• Q86X29
• A6NDW3
• B4DKL4
• E9PHD4
• O00112
• O00426
• Q6ZT80
• Q8NBM0
• Q9BT33
• Q9UQL3

Gene Name

• LSR

Ensembl ID

• ENST00000347609
• ENSP00000262627
• ENSG00000105699
• ENST00000354900
• ENSP00000346976
• ENST00000360798
• ENSP00000354034
• ENST00000361790
• ENSP00000354575
• ENST00000427250
• ENSP00000394479
• ENST00000602122
• ENSP00000472569
• ENST00000621372
• ENSP00000480821

Symbol

• LISCH
• ILDR3
• LISCH7

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.75
transcription factor perturbation	0.74
transcription factor binding site profile	0.73
histone modification site profile	0.72
tissue	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.23   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 248.23   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0