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Tdark
LSMEM2
Leucine-rich single-pass membrane protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316436
  • ENSP00000315081
  • ENSG00000179564

Symbol
  • C3orf45
  • C3orf45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
tissue sample
0.48
cell line
0.44
microRNA
0.38
interacting protein
0.31


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.01   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 24   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.01   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 24   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
MOSPD2
Tbio
Novelty:  0.14602473
p_int:  0.999999986
p_ni:  1.4e-8
Data Source:  BioPlex
ENPP4
Tbio
Family:  Enzyme
Novelty:  0.09897251
p_int:  0.999999859
p_ni:  2.7e-8
p_wrong:  1.14e-7
Data Source:  BioPlex
IST1
Tbio
Novelty:  0.01780503
p_int:  0.999999603
p_ni:  3.68e-7
p_wrong:  2.9e-8
Data Source:  BioPlex
GRAMD1B
Tbio
Novelty:  0.2994102
p_int:  0.999995054
p_ni:  0.000004944
p_wrong:  2e-9
Data Source:  BioPlex
ADAM22
Tbio
Family:  Enzyme
Novelty:  0.01981755
p_int:  0.99997288
p_ni:  0.000026149
p_wrong:  9.71e-7
Data Source:  BioPlex
RNF149
Tdark
Family:  Enzyme
Novelty:  0.64503076
p_int:  0.999828741
p_ni:  0.000171253
p_wrong:  5e-9
Data Source:  BioPlex
STX3
Tbio
Novelty:  0.01055819
p_int:  0.999437419
p_ni:  0.000121614
p_wrong:  0.000440967
Data Source:  BioPlex
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999092259
p_ni:  0.000066928
p_wrong:  0.000840813
Data Source:  BioPlex
LSR
Tbio
Novelty:  0.00528058
p_int:  0.994275466
p_ni:  0.005724534
Data Source:  BioPlex
PLD3
Tbio
Family:  Enzyme
Novelty:  0.01610007
p_int:  0.989712457
p_ni:  0.010287543
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
7
14
99.5
reticulocyte count
2
4
8
98.7
mean reticulocyte volume
1
1
1
85.1
chronotype measurement
1
2
0
1
78.7
macrophage inflammatory protein 1b measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
14
99.5
reticulocyte count
8
98.7
mean reticulocyte volume
1
85.1
chronotype measurement
0
1
78.7
macrophage inflammatory protein 1b measurement
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 0.01
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title