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Tbio
LSM7
U6 snRNA-associated Sm-like protein LSm7

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252622
  • ENSP00000252622
  • ENSG00000130332

Symbol
  • YNL147W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
kinase perturbation
0.84
interacting protein
0.83
co-expressed gene
0.82
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (291)
PATL1
Tbio
Novelty:  0.10847
p_int:  0.999999756
p_ni:  2.44e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999997519
p_ni:  0.000002479
p_wrong:  2e-9
Data Source:  BioPlex
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999996142
p_ni:  0.000003858
Data Source:  BioPlex
ZNF511
Tdark
Novelty:  1.07235474
p_int:  0.99997252
p_ni:  8.73e-7
p_wrong:  0.000026607
Data Source:  BioPlex
LSM1
Tbio
Novelty:  0.00962392
p_int:  0.99990471
p_ni:  0.00009529
Score:  0.999
Data Source:  BioPlex,STRINGDB
NAA38
Tdark
Family:  Enzyme
Novelty:  19.36506889
p_int:  0.99987672
p_ni:  0.00012328
Score:  0.978
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999863796
p_ni:  0.000136204
Score:  0.997
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.999700557
p_ni:  0.00029942
p_wrong:  2.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM2
Tbio
Novelty:  0.03339237
p_int:  0.999587644
p_ni:  0.000412356
Score:  0.999
Data Source:  BioPlex,STRINGDB
MEPCE
Tbio
Novelty:  0.05592081
p_int:  0.999571322
p_ni:  0.000428678
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
2
2
75.7
body mass index
2
2
2
72.8
self reported educational attainment
1
1
1
44.2
body height
1
1
1
35
age-related hearing impairment
1
1
0
5.9
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
2
75.7
body mass index
2
72.8
self reported educational attainment
1
44.2
body height
1
35
age-related hearing impairment
0
5.9
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:6635
455572
Mouse
MGI:1913344
66094
Rat
RGD:1305354
362829
Dog
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:42846
612170
Cow
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:31059
509920
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Mouse
Rat
Dog
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Cow
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
Publication Statistics
PubMed Score 8.54
PubMed score by year
PubTator Score 5.11
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title