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Tbio
LSM6
U6 snRNA-associated Sm-like protein LSm6

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway (Probable). Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like prot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296581
  • ENSP00000296581
  • ENSG00000164167
  • ENST00000502781
  • ENSP00000422392
  • ENST00000504181
  • ENSP00000420929
  • ENST00000515311
  • ENSP00000427036
  • ENST00000649747
  • ENSP00000497311

Symbol
  • YDR378C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
interacting protein
0.84
cell type or tissue
0.75
transcription factor perturbation
0.74
tissue sample
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.32   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (290)
PATL1
Tbio
Novelty:  0.10847
p_int:  0.999999998
p_ni:  2e-9
Score:  0.99
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999998684
p_ni:  0.000001316
Score:  0.85
Data Source:  BioPlex,STRINGDB
Q9P0M2
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999997378
p_ni:  0.000002592
p_wrong:  3e-8
Score:  0.71
Data Source:  BioPlex,STRINGDB
LSM1
Tbio
Novelty:  0.00962392
p_int:  0.999996944
p_ni:  0.000003056
Score:  0.999
Data Source:  BioPlex,STRINGDB
CLNS1A
Tbio
Novelty:  0.01824362
p_int:  0.999993427
p_ni:  0.000006573
Score:  0.852
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999987773
p_ni:  0.000012227
Score:  0.998
Data Source:  BioPlex,STRINGDB
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.99998531
p_ni:  0.00001469
Data Source:  BioPlex
SART3
Tbio
Novelty:  0.02353492
p_int:  0.999957463
p_ni:  0.000042537
Score:  0.938
Data Source:  BioPlex,STRINGDB
LSM2
Tbio
Novelty:  0.03339237
p_int:  0.999938867
p_ni:  0.000061133
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deadenylation-dependent mRNA decay (R-HSA-429914)

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Find Similar Targets
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:630
100613876
Mouse
MGI:1925901
78651
Dog
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:42845
612329
Horse
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:19822
100629585
Cow
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:31058
615916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Mouse
Dog
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Horse
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Cow
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
Publication Statistics
PubMed Score 8.32
PubMed score by year
PubTator Score 5.56
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title