You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LSM5
U6 snRNA-associated Sm-like protein LSm5

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409292
  • ENSP00000386814
  • ENSG00000106355
  • ENST00000409782
  • ENSP00000387109
  • ENST00000409909
  • ENSP00000386363
  • ENST00000409952
  • ENSP00000387126
  • ENST00000410044
  • ENSP00000386707
  • ENST00000450169
  • ENSP00000410758

Symbol
  • YER146W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.72
transcription factor binding site profile
0.72
transcription factor perturbation
0.61
kinase perturbation
0.6
small molecule perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (278)
PATL1
Tbio
Novelty:  0.10847
p_int:  0.99999999
p_ni:  1e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
POLH
Tchem
Family:  Enzyme
Novelty:  0.00458533
p_int:  0.999999988
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999999982
p_ni:  1.8e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
ZNF511
Tdark
Novelty:  1.07235474
p_int:  0.999999668
p_ni:  1.2e-8
p_wrong:  3.19e-7
Score:  0.485
Data Source:  BioPlex,STRINGDB
Q9P0M2
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999999214
p_ni:  7.85e-7
Score:  0.549
Data Source:  BioPlex,STRINGDB
LSM1
Tbio
Novelty:  0.00962392
p_int:  0.99999893
p_ni:  0.00000107
Score:  0.999
Data Source:  BioPlex,STRINGDB
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999998033
p_ni:  0.000001967
Score:  0.711
Data Source:  BioPlex,STRINGDB
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
p_int:  0.999989773
p_ni:  0.000010227
Score:  0.541
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.999862482
p_ni:  0.000137518
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM4
Tbio
Novelty:  0.00616897
p_int:  0.999773897
p_ni:  0.000226103
Score:  0.999
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
3
3
59.5
intelligence
4
3
1
5.7
58.2
mathematical ability
2
2
2
44.1
cognitive function measurement
3
1
3
11.3
1
1
1
8.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
59.5
intelligence
1
5.7
58.2
mathematical ability
2
44.1
cognitive function measurement
3
11.3
1
8.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:4420
463335
Macaque
U6 snRNA-associated Sm-like protein LSm5
702299
Mouse
MGI:1913623
66373
Horse
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:19821
100055259
Cow
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:31057
615136
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Macaque
U6 snRNA-associated Sm-like protein LSm5
Mouse
Horse
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Cow
LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated
Publication Statistics
PubMed Score 6.18
PubMed score by year
PubTator Score 3.64
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title