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Tbio
LSM4
U6 snRNA-associated Sm-like protein LSm4

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000593829
  • ENSP00000469468
  • ENSG00000130520

Symbol
  • GRP
  • YER112W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor binding site profile
0.96
kinase perturbation
0.93
co-expressed gene
0.69
small molecule perturbation
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.92   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 156.92   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (315)
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999862118
p_ni:  0.000137882
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.999773897
p_ni:  0.000226103
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.998984377
p_ni:  0.001015618
p_wrong:  5e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.997851916
p_ni:  0.002148084
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.976646621
p_ni:  0.023353379
Score:  0.999
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.939122907
p_ni:  0.060877093
Score:  0.981
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.936562268
p_ni:  0.063437732
Score:  0.996
Data Source:  BioPlex,STRINGDB
PRPF4
Tchem
Novelty:  0.08229072
p_int:  0.86056252
p_ni:  0.13943748
Score:  0.996
Data Source:  BioPlex,STRINGDB
LSM1
Tbio
Novelty:  0.00962392
Score:  0.999
Data Source:  STRINGDB
SNRPF
Tdark
Novelty:  0.17624854
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Deadenylation-dependent mRNA decay (R-HSA-429914)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (60)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
4
6
7
99.3
BMI-adjusted waist-hip ratio
9
12
20
98.1
waist-hip ratio
5
12
14
98
monocyte count
3
3
4
94.2
waist circumference
1
6
6
93.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
growth differentiation factor 15 measurement
7
99.3
BMI-adjusted waist-hip ratio
20
98.1
waist-hip ratio
14
98
monocyte count
4
94.2
waist circumference
6
93.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
747984
Macaque
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
720192
Mouse
MGI:1354692
50783
Rat
RGD:1306808
290647
Dog
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:42844
609922
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Macaque
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Mouse
Rat
Dog
LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
Publication Statistics
PubMed Score 156.92
PubMed score by year
PubTator Score 17.21
PubTator score by year
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Related Publications
Items per page:
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PMID
Year
Title