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Tbio
LSM3
U6 snRNA-associated Sm-like protein LSm3

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306024
  • ENSP00000302160
  • ENSG00000170860

Symbol
  • SMX4
  • USS2
  • YLR438C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
disease perturbation
0.98
interacting protein
0.96
histone modification site profile
0.81
kinase perturbation
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.85   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.85   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (371)
PATL1
Tbio
Novelty:  0.10847
p_int:  0.999999957
p_ni:  4.3e-8
Score:  0.993
Data Source:  BioPlex,STRINGDB
TNFAIP1
Tbio
Novelty:  0.04006419
p_int:  0.999999944
p_ni:  5.5e-8
p_wrong:  1e-9
Data Source:  BioPlex
LSM10
Tbio
Novelty:  0.16403413
p_int:  0.999999904
p_ni:  8.6e-8
p_wrong:  1e-8
Score:  0.971
Data Source:  BioPlex,STRINGDB
KCTD13
Tbio
Novelty:  0.07000508
p_int:  0.999999856
p_ni:  1e-7
p_wrong:  4.4e-8
Data Source:  BioPlex
DPCD
Tbio
Novelty:  0.09869683
p_int:  0.999998842
p_ni:  0.000001153
p_wrong:  6e-9
Data Source:  BioPlex
ALDH1A3
Tchem
Family:  Enzyme
Novelty:  0.00691116
p_int:  0.999998671
p_ni:  0.000001329
Data Source:  BioPlex
LSM1
Tbio
Novelty:  0.00962392
p_int:  0.999994144
p_ni:  0.000005842
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,STRINGDB
O43687
Tbio
Family:  Enzyme
Novelty:  0.04114095
p_int:  0.999984822
p_ni:  0.000015178
Data Source:  BioPlex
TUT1
Tbio
Family:  Enzyme
Novelty:  0.01436913
p_int:  0.999968166
p_ni:  0.000031827
p_wrong:  7e-9
Data Source:  BioPlex
CEP95
Tdark
Novelty:  1.18897795
p_int:  0.999958105
p_ni:  0.000041893
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Deadenylation-dependent mRNA decay (R-HSA-429914)

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Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.2
79.2
longevity
1
1
1
43.1
IGF-1 measurement
1
1
1
37
heel bone mineral density
1
1
1
34.9
glomerular filtration rate
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
79.2
longevity
1
43.1
IGF-1 measurement
1
37
heel bone mineral density
1
34.9
glomerular filtration rate
1
21.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:7982
742889
Macaque
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
701060
Mouse
MGI:1914928
67678
Rat
RGD:1305971
297455
Dog
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:42843
607248
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Macaque
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Mouse
Rat
Dog
LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Publication Statistics
PubMed Score 30.85
PubMed score by year
PubTator Score 5.90
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title