You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
LSM2
U6 snRNA-associated Sm-like protein LSm2

Protein Summary
Description
Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex) (PubMed:28781166). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA (PubMed:10523320). This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 19. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375661
  • ENSP00000364813
  • ENSG00000204392
  • ENST00000383391
  • ENSP00000372883
  • ENSG00000172850
  • ENST00000424975
  • ENSP00000403345
  • ENSG00000231502
  • ENST00000432122
  • ENSP00000414006
  • ENSG00000224979
  • ENST00000434125
  • ENSP00000406280
  • ENSG00000225998
  • ENST00000455705
  • ENSP00000414634
  • ENSG00000236826

Symbol
  • C6orf28
  • G7B
  • G7B
  • snRNP
  • C6orf28
  • YBL026W
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
co-expressed gene
0.97
kinase perturbation
0.93
disease perturbation
0.83
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.15   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.15   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (300)
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999949096
p_ni:  0.000050904
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM6
Tbio
Novelty:  0.09507671
p_int:  0.999938867
p_ni:  0.000061133
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM7
Tbio
Novelty:  0.09112723
p_int:  0.999587644
p_ni:  0.000412356
Score:  0.999
Data Source:  BioPlex,STRINGDB
LSM5
Tbio
Novelty:  0.12669584
p_int:  0.99926046
p_ni:  0.00073954
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRPF3
Tbio
Novelty:  0.01600014
p_int:  0.977705066
p_ni:  0.022294933
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPE
Tbio
Novelty:  0.02033423
p_int:  0.966048747
p_ni:  0.033951253
Score:  0.999
Data Source:  BioPlex,STRINGDB
SART3
Tbio
Novelty:  0.02353492
p_int:  0.944000414
p_ni:  0.055999586
Score:  0.991
Data Source:  BioPlex,STRINGDB
SNRPF
Tbio
Novelty:  0.17624854
p_int:  0.939314707
p_ni:  0.060685293
Score:  0.999
Data Source:  BioPlex,STRINGDB
SNRPN
Tbio
Novelty:  0.002157
p_int:  0.932153526
p_ni:  0.067846474
Score:  0.996
Data Source:  BioPlex,STRINGDB
LSM4
Tbio
Novelty:  0.00616897
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Deadenylation-dependent mRNA decay (R-HSA-429914)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deadenylation-dependent mRNA decay
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Deadenylation-dependent mRNA decay
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (468)
Items per page:
1 – 5 of 468
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
2.3
98.5
3
3
0
2.3
98.5
3
3
0
2.3
98.5
3
3
0
2.3
98.5
3
3
0
2.3
98.5
Items per page:
1 – 5 of 468
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.3
98.5
0
2.3
98.5
0
2.3
98.5
0
2.3
98.5
0
2.3
98.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
VGNC:12652
462569
Macaque
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
715592
Mouse
MGI:90676
27756
Rat
RGD:1598536
684148
Horse
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:13940]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Macaque
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
Mouse
Rat
Horse
LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated [Source:HGNC Symbol;Acc:HGNC:13940]
Publication Statistics
PubMed Score 44.15
PubMed score by year
PubTator Score 383.66
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title