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Tbio
LSM14A
Protein LSM14 homolog A

Protein Summary
Description
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433627
  • ENSP00000413964
  • ENSG00000257103
  • ENST00000540746
  • ENSP00000446451
  • ENST00000544216
  • ENSP00000446271
  • ENST00000570462
  • ENSP00000459843
  • ENSG00000262860
  • ENST00000575811
  • ENSP00000461225

Symbol
  • C19orf13
  • FAM61A
  • RAP55
  • RAP55A
  • RAP55
  • FAM61A
  • RAP55A
  • C19orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.94
protein domain
0.85
ligand (protein) perturbation
0.83
microRNA
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0