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Tbio
LSM14A
Protein LSM14 homolog A

Protein Summary
Description
Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for non-translating mRNAs. Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000433627
  • ENSP00000413964
  • ENSG00000257103
  • ENST00000540746
  • ENSP00000446451
  • ENST00000544216
  • ENSP00000446271
  • ENST00000570462
  • ENSP00000459843
  • ENSG00000262860
  • ENST00000575811
  • ENSP00000461225

Symbol
  • C19orf13
  • FAM61A
  • RAP55
  • RAP55A
  • RAP55
  • FAM61A
  • RAP55A
  • C19orf13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
0.94
protein domain
0.85
ligand (protein) perturbation
0.83
microRNA
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.81   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 150   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.81   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 150   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.997878003
p_ni:  0.002121997
Score:  0.549
Data Source:  BioPlex,STRINGDB
SFPQ
Tbio
Novelty:  0.01207637
p_int:  0.993864477
p_ni:  0.006135523
Score:  0.244
Data Source:  BioPlex,STRINGDB
STRAP
Tbio
Family:  Enzyme
Novelty:  0.0336013
p_int:  0.927819355
p_ni:  0.072180645
Score:  0.432
Data Source:  BioPlex,STRINGDB
EIF4ENIF1
Tbio
Novelty:  0.03835664
Score:  0.992
Data Source:  STRINGDB
DDX6
Tbio
Family:  Enzyme
Novelty:  0.01032357
Score:  0.98
Data Source:  STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
Score:  0.966
Data Source:  STRINGDB
EDC3
Tbio
Novelty:  0.02077346
Score:  0.933
Data Source:  STRINGDB
PATL1
Tbio
Novelty:  0.10847
Score:  0.898
Data Source:  STRINGDB
XRN1
Tbio
Family:  Enzyme
Novelty:  0.00409381
Score:  0.884
Data Source:  STRINGDB
LSM1
Tbio
Novelty:  0.00962392
Score:  0.874
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
80
red blood cell distribution width
2
2
2
80
reticulocyte measurement
1
1
1
54.4
heel bone mineral density
1
1
1
54.4
heel bone mineral density
1
1
1
54.4
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
80
red blood cell distribution width
2
80
reticulocyte measurement
1
54.4
heel bone mineral density
1
54.4
heel bone mineral density
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LSM14A, mRNA processing body assembly factor
VGNC:13206
455937
Macaque
LSM14A, mRNA processing body assembly factor
705085
Mouse
MGI:1914320
67070
Rat
RGD:1305695
361554
Dog
LSM14A, mRNA processing body assembly factor
VGNC:42841
476492
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LSM14A, mRNA processing body assembly factor
Macaque
LSM14A, mRNA processing body assembly factor
Mouse
Rat
Dog
LSM14A, mRNA processing body assembly factor
Publication Statistics
PubMed Score 22.81
PubMed score by year
PubTator Score 12.26
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title