Tbio LRRTM4 Leucine-rich repeat transmembrane neuronal protein 4

Protein Summary

Description

May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).

Uniprot Accession IDs

• Q86VH4
• Q4FZ98
• Q6UXJ7

Gene Name

• LRRTM4

Ensembl ID

• ENST00000409088
• ENSP00000386236
• ENSG00000176204
• ENST00000409093
• ENSP00000386357
• ENST00000409884
• ENSP00000387297

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
trait	0.86
microRNA	0.82
cellular component	0.59
transcription factor	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / Leucine-rich Repeat Transmembrane Neuronal Protein 4

Protein / Extracellular Matrix Protein / Leucine-rich Repeat Transmembrane Neuronal Protein 4

DTO Classes

Protein / Receptor / Leucine-rich Repeat Transmembrane Neuronal Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.64   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.64   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0