Tbio LRRTM4 Leucine-rich repeat transmembrane neuronal protein 4

Protein Summary

Description

May play a role in the development and maintenance of the vertebrate nervous system. Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation (By similarity).

Uniprot Accession IDs

• Q86VH4
• Q4FZ98
• Q6UXJ7

Gene Name

• LRRTM4

Ensembl ID

• ENST00000409088
• ENSP00000386236
• ENSG00000176204
• ENST00000409093
• ENSP00000386357
• ENST00000409884
• ENSP00000387297

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.86
trait	0.86
microRNA	0.82
cellular component	0.59
transcription factor	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / Leucine-rich Repeat Transmembrane Neuronal Protein 4

Protein / Extracellular Matrix Protein / Leucine-rich Repeat Transmembrane Neuronal Protein 4

DTO Classes

Protein / Receptor / Leucine-rich Repeat Transmembrane Neuronal Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 95   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (64)

Explore Interacting Targets

1 – 10 of 64

• See Interactions on String-DB

USP34

Tbio

Family:  Enzyme

Novelty:  0.16444192

p_int:  0.999995623

p_ni:  0.000004377

Data Source:  BioPlex

CCNL2

Tbio

Novelty:  0.03667817

p_int:  0.9999942

p_ni:  0.000005235

p_wrong:  5.66e-7

Data Source:  BioPlex

LRRTM3

Tbio

Novelty:  0.18633527

p_int:  0.999990346

p_ni:  5e-9

p_wrong:  0.000009649

Data Source:  BioPlex

GPC1

Tbio

Novelty:  0.00293087

p_int:  0.999675416

p_ni:  0.000077635

p_wrong:  0.000246949

Score:  0.647

Data Source:  BioPlex,STRINGDB

CNPY4

Tdark

Novelty:  0.59578334

p_int:  0.999607431

p_ni:  0.000189699

p_wrong:  0.00020287

Data Source:  BioPlex

GPC3

Tbio

Novelty:  0.00151823

p_int:  0.999528347

p_ni:  0.000471652

p_wrong:  1e-9

Score:  0.333

Data Source:  BioPlex,STRINGDB

Q9HDB5

Tbio

Novelty:  0.00999084

p_int:  0.999417674

p_ni:  0.000497671

p_wrong:  0.000084655

Score:  0.948

Data Source:  BioPlex,STRINGDB

PPP4R3A

Tbio

Family:  Enzyme

Novelty:  0.04234592

p_int:  0.999249034

p_ni:  0.000750966

Data Source:  BioPlex

CENPB

Tbio

Novelty:  0.0036225

p_int:  0.999023527

p_ni:  0.000976409

p_wrong:  6.4e-8

Data Source:  BioPlex

CDK11B

Tchem

Family:  Kinase

Novelty:  0.02711308

p_int:  0.998847791

p_ni:  0.001152209

Data Source:  BioPlex

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Neurexins and neuroligins (R-HSA-6794361)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Neurexins and neuroligins	60 targets	R-HSA-6794361
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Protein-protein interactions at synapses	91 targets	R-HSA-6794362

Name	Explore in Pharos	Explore in Source
Neurexins and neuroligins	60 targets	R-HSA-6794361
Neuronal System	398 targets	R-HSA-112316
Protein-protein interactions at synapses	91 targets	R-HSA-6794362

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (5)

Components (5)

Find Similar Targets

Items per page:

10

1 – 5 of 5

GO Term	Evidence	Assigned by
extracellular matrix	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
extracellular space	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
cell junction	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
postsynaptic membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	3	5	3	1	91.9
comparative body size at age 10, self-reported	EFO_0009819	1	1	1		63.7
peripheral arterial disease	EFO_0004265	1	1	0	22.3	45.7
traffic air pollution measurement	EFO_0007908	1	1	0	22.3	45.7
risk-taking behaviour	EFO_0008579	2	2	2		40.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
chronotype measurement	EFO_0008328	3	1	91.9
comparative body size at age 10, self-reported	EFO_0009819	1		63.7
peripheral arterial disease	EFO_0004265	0	22.3	45.7
traffic air pollution measurement	EFO_0007908	0	22.3	45.7
risk-taking behaviour	EFO_0008579	2		40.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell junction
Cell membrane
Complete proteome
Glycoprotein
Leucine-rich repeat
Membrane
Postsynaptic cell membrane
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
chronotype measurement
comparative body size at age 10, self-reported
diet measurement
insomnia measurement
mathematical ability
peripheral arterial disease
risk-taking behaviour
risky sexual behaviour measurement
traffic air pollution measurement

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat transmembrane neuronal 4	VGNC:10720	470414
Macaque	leucine rich repeat transmembrane neuronal 4 [Source:HGNC Symbol;Acc:HGNC:19411]
Mouse	leucine rich repeat transmembrane neuronal 4	MGI:2389180	243499
Rat	leucine rich repeat transmembrane neuronal 4	RGD:1560707	500219
Dog	leucine rich repeat transmembrane neuronal 4	VGNC:42832	483091

Species	Name	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat transmembrane neuronal 4
Macaque	leucine rich repeat transmembrane neuronal 4 [Source:HGNC Symbol;Acc:HGNC:19411]
Mouse	leucine rich repeat transmembrane neuronal 4
Rat	leucine rich repeat transmembrane neuronal 4
Dog	leucine rich repeat transmembrane neuronal 4

Publication Statistics

PubMed Score 14.76

PubMed score by year

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PubTator Score 5.92

PubTator score by year

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Related Publications

Text Mined References (10)

GeneRif Annotations (1)

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10

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PMID	Year	Title