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Tbio
LRRTM2
Leucine-rich repeat transmembrane neuronal protein 2

Protein Summary
Description
Involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. Regulates surface expression of AMPA receptors and instructs the development of functional glutamate release sites. Acts as a ligand for the presynaptic receptors NRXN1-A and NRXN1-B (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274711
  • ENSP00000274711
  • ENSG00000146006

Symbol
  • KIAA0416
  • LRRN2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.77
gene perturbation
0.67
cell line
0.65
cell type or tissue
0.61
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.67   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.67   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
TMEM38B
Tbio
Family:  IC
Novelty:  0.0691148
p_int:  0.999458537
p_ni:  0.000541462
p_wrong:  1e-9
Score:  0.527
Data Source:  BioPlex,STRINGDB
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.995410001
p_ni:  0.004589999
Score:  0.184
Data Source:  BioPlex,STRINGDB
CNPY4
Tdark
Novelty:  0.59578334
p_int:  0.993564601
p_ni:  0.000172556
p_wrong:  0.006262843
Score:  0.221
Data Source:  BioPlex,STRINGDB
GPC3
Tbio
Novelty:  0.00151823
p_int:  0.991983961
p_ni:  0.008015974
p_wrong:  6.5e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
p_int:  0.888094379
p_ni:  0.111291159
p_wrong:  0.000614461
Score:  0.3
Data Source:  BioPlex,STRINGDB
DAD1
Tbio
Family:  Enzyme
Novelty:  0.00653242
p_int:  0.809042168
p_ni:  0.190741701
p_wrong:  0.000216131
Score:  0.199
Data Source:  BioPlex,STRINGDB
LGR4
Tbio
Family:  GPCR
Novelty:  0.01180123
p_int:  0.774336333
p_ni:  0.225165827
p_wrong:  0.00049784
Score:  0.186
Data Source:  BioPlex,STRINGDB
P58400
Tbio
Novelty:  0.00454659
Score:  0.985
Data Source:  STRINGDB
Q9ULB1
Tbio
Novelty:  0.00454659
Score:  0.985
Data Source:  STRINGDB
Q9HDB5
Tbio
Novelty:  0.00999084
Score:  0.983
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neurexins and neuroligins (R-HSA-6794361)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
1
1
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
risk-taking behaviour
1
52.4
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat transmembrane neuronal 2
VGNC:4076
746417
Macaque
leucine rich repeat transmembrane neuronal 2 [Source:HGNC Symbol;Acc:HGNC:19409]
Mouse
MGI:2389174
107065
Rat
RGD:1593785
685472
Dog
leucine rich repeat transmembrane neuronal 2
VGNC:42830
481529
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat transmembrane neuronal 2
Macaque
leucine rich repeat transmembrane neuronal 2 [Source:HGNC Symbol;Acc:HGNC:19409]
Mouse
Rat
Dog
leucine rich repeat transmembrane neuronal 2
Publication Statistics
PubMed Score 16.67
PubMed score by year
PubTator Score 4.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title