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Tbio
LRRTM1
Leucine-rich repeat transmembrane neuronal protein 1

Protein Summary
Description
Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295057
  • ENSP00000295057
  • ENSG00000162951
  • ENST00000409148
  • ENSP00000386646
  • ENST00000417012
  • ENSP00000393562
  • ENST00000433224
  • ENSP00000414523
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.56
transcription factor
0.56
cell type or tissue
0.54
cellular component
0.54
cell line
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.07   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.07   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
AREL1
Tdark
Family:  Enzyme
Novelty:  0.31082841
p_int:  0.999586279
p_ni:  0.000171029
p_wrong:  0.000242692
Score:  0.194
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.99910368
p_ni:  0.00089632
Score:  0.177
Data Source:  BioPlex,STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
p_int:  0.998824579
p_ni:  0.001175281
p_wrong:  1.39e-7
Data Source:  BioPlex
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.998797489
p_ni:  0.001202511
Data Source:  BioPlex
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.997955858
p_ni:  0.002044127
p_wrong:  1.5e-8
Score:  0.186
Data Source:  BioPlex,STRINGDB
MARC1
Tbio
Novelty:  0.05568181
p_int:  0.997921847
p_ni:  0.002078153
Data Source:  BioPlex
RAB12
Tbio
Family:  Enzyme
Novelty:  0.05361391
p_int:  0.994514259
p_ni:  0.000584359
p_wrong:  0.004901382
Score:  0.259
Data Source:  BioPlex,STRINGDB
C1orf43
Tbio
Novelty:  0.13587458
p_int:  0.992169109
p_ni:  0.007830797
p_wrong:  9.4e-8
Data Source:  BioPlex
TYW1
Tbio
Family:  Enzyme
Novelty:  0.05117274
p_int:  0.991597388
p_ni:  0.008402612
Data Source:  BioPlex
NSUN3
Tbio
Family:  Enzyme
Novelty:  0.15268529
p_int:  0.988864835
p_ni:  0.010245885
p_wrong:  0.00088928
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neurexins and neuroligins (R-HSA-6794361)

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Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (19)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SynGO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
SynGO
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
66.6
cognitive function measurement
1
1
1
28.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
66.6
cognitive function measurement
1
28.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat transmembrane neuronal 1
VGNC:292
459351
Macaque
leucine rich repeat transmembrane neuronal 1
712198
Mouse
MGI:2389173
74342
Rat
RGD:1585921
679668
Dog
leucine rich repeat transmembrane neuronal 1
VGNC:42829
483089
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat transmembrane neuronal 1
Macaque
leucine rich repeat transmembrane neuronal 1
Mouse
Rat
Dog
leucine rich repeat transmembrane neuronal 1
Publication Statistics
PubMed Score 27.07
PubMed score by year
PubTator Score 14.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title