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Tdark
LRRN2
Leucine-rich repeat neuronal protein 2

Protein Summary
Description
The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367175
  • ENSP00000356143
  • ENSG00000170382
  • ENST00000367176
  • ENSP00000356144
  • ENST00000367177
  • ENSP00000356145

Symbol
  • GAC1
  • LRRN5
  • GAC1
  • LRRN5
  • LRANK1
  • FIGLER7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.7
tissue
0.61
tissue sample
0.61
cell line
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.64   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.64   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (46)
XIAP
Tchem
Family:  Enzyme
Novelty:  0.00062268
p_int:  0.999995685
p_ni:  0.000004314
p_wrong:  1e-9
Score:  0.536
Data Source:  BioPlex,STRINGDB
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.999963181
p_ni:  0.000036818
p_wrong:  1e-9
Score:  0.341
Data Source:  BioPlex,STRINGDB
TRIM13
Tbio
Family:  Enzyme
Novelty:  0.00085649
p_int:  0.999660006
p_ni:  0.000202868
p_wrong:  0.000137126
Score:  0.167
Data Source:  BioPlex,STRINGDB
ETNK1
Tbio
Family:  Kinase
Novelty:  0.04817798
p_int:  0.980207205
p_ni:  0.01733158
p_wrong:  0.002461215
Score:  0.274
Data Source:  BioPlex,STRINGDB
LRIG3
Tbio
Novelty:  0.04502029
p_int:  0.977789604
p_ni:  0.022210396
Score:  0.308
Data Source:  BioPlex,STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
p_int:  0.975625592
p_ni:  0.024374408
Data Source:  BioPlex
ST7L
Tbio
Novelty:  0.03661324
p_int:  0.968936589
p_ni:  0.031063361
p_wrong:  5e-8
Data Source:  BioPlex
TRAF2
Tbio
Novelty:  0.00983658
p_int:  0.967229304
p_ni:  0.032770695
Score:  0.179
Data Source:  BioPlex,STRINGDB
FGFR1
Tclin
Family:  Kinase
Novelty:  0.00055714
p_int:  0.945484985
p_ni:  0.054513877
p_wrong:  0.000001138
Score:  0.24
Data Source:  BioPlex,STRINGDB
USP22
Tbio
Family:  Enzyme
Novelty:  0.01416662
p_int:  0.900855654
p_ni:  0.093549026
p_wrong:  0.005595319
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
4
4
3.5
94.7
mathematical ability
4
3
4
89.5
household income
2
3
4
80.4
intelligence
3
2
2
6
79.2
3
1
0
1.1
76.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
3.5
94.7
mathematical ability
4
89.5
household income
4
80.4
intelligence
2
6
79.2
0
1.1
76.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat neuronal 2
VGNC:11528
104004696
Mouse
MGI:106037
16980
Rat
RGD:1305482
289020
Dog
leucine rich repeat neuronal 2
VGNC:42825
488564
Horse
leucine rich repeat neuronal 2
VGNC:19803
100054439
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat neuronal 2
Mouse
Rat
Dog
leucine rich repeat neuronal 2
Horse
leucine rich repeat neuronal 2
Publication Statistics
PubMed Score 4.64
PubMed score by year
PubTator Score 1.70
PubTator score by year
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Related Publications
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PMID
Year
Title