Tchem LRRK2 Leucine-rich repeat serine/threonine-protein kinase 2

Protein Summary

Description

Positively regulates autophagy through a calcium-dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Plays a role in synaptic vesicle trafficking. Phosphorylates PRDX3. Has GTPase activity. May play a role in the phosphorylation of proteins central to Parkinson disease. Plays an important role in recuiting SEC16A to endoplasmic reticulum exit sites (ERES) and in regulating ER to Golgi vesicle-mediated transport and ERES organization (PubMed:25201882). This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5S007
• A6NJU2
• Q6ZS50
• Q8NCX9

Gene Name

• LRRK2

Ensembl ID

• ENST00000298910
• ENSP00000298910
• ENSG00000188906

Symbol

• PARK8
• PARK8
• RIPK7
• ROCO2
• AURA17
• DARDARIN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	1
protein domain	1
cellular component	0.93
drug perturbation	0.87

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tkl Group / Lrrk Family / Leucine-rich Repeat Serine/threonine-protein Kinase 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2119.59   (req: < 5)

Gene RIFs: 973   (req: <= 3)

Antibodies: 804   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2119.59   (req: >= 5)

Gene RIFs: 973   (req: > 3)

Antibodies: 804   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 118

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1022

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2