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Tbio
LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

Protein Summary
Description
This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388948
  • ENSP00000373600
  • ENSG00000154237
  • ENST00000532029
  • ENSP00000433268

Symbol
  • KIAA1790
  • RIPK6
  • Roco1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.99
molecular function
0.97
PubMedID
0.87
transcription factor binding site profile
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.92   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.92   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (6)
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (72)
CDK5RAP2
Tbio
Novelty:  0.00956263
Score:  0.772
Data Source:  STRINGDB
PINK1
Tbio
Family:  Kinase
Novelty:  0.00100973
Score:  0.741
Data Source:  STRINGDB
SFN
Tbio
Novelty:  0.00340233
Score:  0.737
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.73
Data Source:  STRINGDB
GTPBP4
Tchem
Novelty:  0.00062563
Score:  0.72
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
VPS35
Tbio
Novelty:  0.00729892
Score:  0.671
Data Source:  STRINGDB
PARK7
Tbio
Family:  Enzyme
Novelty:  0.00104651
Score:  0.666
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
3
2
0
3.6
90.9
monocyte percentage of leukocytes
2
1
2
80.6
corneal topography
1
1
1
71
granulocyte percentage of myeloid white cells
1
1
1
67.8
BMI-adjusted hip circumference
2
1
2
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3.6
90.9
monocyte percentage of leukocytes
2
80.6
corneal topography
1
71
granulocyte percentage of myeloid white cells
1
67.8
BMI-adjusted hip circumference
2
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat kinase 1
453689
Macaque
leucine rich repeat kinase 1
694358
Mouse
MGI:2142227
233328
Rat
RGD:1308000
308703
Dog
leucine rich repeat kinase 1
VGNC:42822
488706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat kinase 1
Macaque
leucine rich repeat kinase 1
Mouse
Rat
Dog
leucine rich repeat kinase 1
Publication Statistics
PubMed Score 23.92
PubMed score by year
PubTator Score 25.95
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title