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Tdark
LRRCC1
Leucine-rich repeat and coiled-coil domain-containing protein 1

Protein Summary
Description
Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis. This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360375
  • ENSP00000353538
  • ENSG00000133739
  • ENST00000414626
  • ENSP00000394695

Symbol
  • CLERC
  • KIAA1764
  • SAP2
  • VFL1
  • CLERC
  • CLERK
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
cell line
0.79
tissue sample
0.67
gene perturbation
0.65
cell type or tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.85   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
MYH7B
Tbio
Novelty:  0.00864941
p_int:  0.99999726
p_ni:  8.2e-8
p_wrong:  0.000002659
Score:  0.365
Data Source:  BioPlex,STRINGDB
ACTN3
Tbio
Novelty:  0.00375035
p_int:  0.999989826
p_ni:  0.000009728
p_wrong:  4.46e-7
Score:  0.224
Data Source:  BioPlex,STRINGDB
PCM1
Tbio
Novelty:  0.02901589
p_int:  0.99997827
p_ni:  0.00002173
Score:  0.198
Data Source:  BioPlex,STRINGDB
CEP131
Tbio
Novelty:  0.02562073
p_int:  0.999973196
p_ni:  0.000026804
Score:  0.183
Data Source:  BioPlex,STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
p_int:  0.999963133
p_ni:  0.000035953
p_wrong:  9.14e-7
Score:  0.206
Data Source:  BioPlex,STRINGDB
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.999948443
p_ni:  0.000051557
Score:  0.18
Data Source:  BioPlex,STRINGDB
POTEE
Tbio
Novelty:  0.29349205
p_int:  0.999932368
p_ni:  0.000067621
p_wrong:  1.1e-8
Score:  0.222
Data Source:  BioPlex,STRINGDB
ANKRD13A
Tbio
Novelty:  0.61940334
p_int:  0.999926778
p_ni:  0.000003364
p_wrong:  0.000069858
Data Source:  BioPlex
ATP2A1
Tchem
Family:  Transporter
Novelty:  0.00355092
p_int:  0.999837991
p_ni:  0.000162009
Score:  0.231
Data Source:  BioPlex,STRINGDB
PIBF1
Tbio
Novelty:  0.0454209
p_int:  0.999701194
p_ni:  0.000298806
Score:  0.204
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
5.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and coiled-coil centrosomal protein 1
VGNC:13176
464262
Macaque
leucine rich repeat and coiled-coil centrosomal protein 1
707964
Mouse
MGI:1918960
71710
Rat
RGD:628722
266808
Dog
leucine rich repeat and coiled-coil centrosomal protein 1
VGNC:54115
487028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and coiled-coil centrosomal protein 1
Macaque
leucine rich repeat and coiled-coil centrosomal protein 1
Mouse
Rat
Dog
leucine rich repeat and coiled-coil centrosomal protein 1
Publication Statistics
PubMed Score 11.85
PubMed score by year
PubTator Score 10.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title