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Tbio
LRRC8E
Volume-regulated anion channel subunit LRRC8E

Protein Summary
Description
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes (PubMed:24790029, PubMed:26824658, PubMed:28193731). The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine (PubMed:24790029, PubMed:26824658). Mediates efflux of amino acids, such as aspartate, in response to osmotic stress (PubMed:28193731). Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition (PubMed:24790029, PubMed:26824658, PubMed:28193731). This gene encodes a member of a small, conserved family of proteins with similar structure, including a string of extracellular leucine-rich repeats. A related protein was shown to be involved in B-cell development. Alternatively spliced transcript variants en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306708
  • ENSP00000306524
  • ENSG00000171017
  • ENST00000618098
  • ENSP00000479953
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.74
histone modification site profile
0.63
protein domain
0.58
cell type or tissue
0.52
small molecule perturbation
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.999997116
p_ni:  0.000002884
Score:  0.187
Data Source:  BioPlex,STRINGDB
DDHD2
Tbio
Family:  Enzyme
Novelty:  0.04306798
p_int:  0.999929739
p_ni:  0.000069966
p_wrong:  2.95e-7
Score:  0.173
Data Source:  BioPlex,STRINGDB
DMD
Tclin
Novelty:  0.00025661
p_int:  0.999391696
p_ni:  0.000608304
Score:  0.18
Data Source:  BioPlex,STRINGDB
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.998506932
p_ni:  0.001493068
Data Source:  BioPlex
OR4D6
Tdark
Family:  oGPCR
Novelty:  1.41130129
p_int:  0.99723531
p_ni:  0.002764689
p_wrong:  1e-9
Data Source:  BioPlex
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.991690771
p_ni:  0.008307452
p_wrong:  0.000001777
Data Source:  BioPlex
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.98943223
p_ni:  0.010567406
p_wrong:  3.64e-7
Data Source:  BioPlex
TRMT6
Tbio
Family:  Enzyme
Novelty:  0.06718902
p_int:  0.986323895
p_ni:  0.013676103
p_wrong:  2e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
FCGR3B
Tbio
Novelty:  0.000429
p_int:  0.984797784
p_ni:  0.015202213
p_wrong:  3e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.982253539
p_ni:  0.017746437
p_wrong:  2.4e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
3
2
1
86.8
sex hormone-binding globulin measurement
4
1
4
67.3
high density lipoprotein cholesterol measurement
1
1
1
45.7
testosterone measurement
1
1
1
42.3
appendicular lean mass
1
1
1
39.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1
86.8
sex hormone-binding globulin measurement
4
67.3
high density lipoprotein cholesterol measurement
1
45.7
testosterone measurement
1
42.3
appendicular lean mass
1
39.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 8 VRAC subunit E
VGNC:11173
469115
Macaque
leucine rich repeat containing 8 VRAC subunit E
706394
Mouse
MGI:1919517
72267
Rat
RGD:1311979
304203
Dog
leucine rich repeat containing 8 VRAC subunit E
VGNC:42818
485003
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 8 VRAC subunit E
Macaque
leucine rich repeat containing 8 VRAC subunit E
Mouse
Rat
Dog
leucine rich repeat containing 8 VRAC subunit E
Publication Statistics
PubMed Score 5.21
PubMed score by year
PubTator Score 1.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title