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Tbio
LRRC8C
Volume-regulated anion channel subunit LRRC8C

Protein Summary
Description
Non-essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and can also conduct organic osmolytes like taurine. Plays a redundant role in the efflux of amino acids, such as aspartate and glutamate, in response to osmotic stress. Channel activity requires LRRC8A plus at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370454
  • ENSP00000359483
  • ENSG00000171488

Symbol
  • AD158
  • FAD158
  • AD158
  • FAD158
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.77
transcription factor perturbation
0.74
PubMedID
0.69
microRNA
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.41   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
LRRC8B
Tbio
Novelty:  0.16457267
p_int:  0.999999902
p_ni:  6.9e-8
p_wrong:  3e-8
Score:  0.196
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999961807
p_ni:  0.000038189
p_wrong:  4e-9
Data Source:  BioPlex
FCGR3B
Tbio
Novelty:  0.000429
p_int:  0.999518124
p_ni:  0.00048186
p_wrong:  1.6e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
HTR3A
Tclin
Family:  IC
Novelty:  0.00217443
p_int:  0.998394738
p_ni:  0.00160428
p_wrong:  9.82e-7
Data Source:  BioPlex
NKAIN1
Tdark
Family:  Enzyme
Novelty:  0.52190272
p_int:  0.997274156
p_ni:  0.000597957
p_wrong:  0.002127887
Data Source:  BioPlex
ZACN
Tchem
Family:  IC
Novelty:  0.21891621
p_int:  0.9946179
p_ni:  0.005374199
p_wrong:  0.000007901
Data Source:  BioPlex
FPR2
Tchem
Family:  GPCR
Novelty:  0.00228744
p_int:  0.954858874
p_ni:  0.008448705
p_wrong:  0.036692421
Data Source:  BioPlex
LRRC8A
Tbio
Novelty:  0.0163093
Score:  0.928
Data Source:  Reactome,STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
4
90.2
monocyte count
1
1
1
74.5
monocyte percentage of leukocytes
1
1
1
54.4
diastolic blood pressure
1
1
1
36.5
heel bone mineral density
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
90.2
monocyte count
1
74.5
monocyte percentage of leukocytes
1
54.4
diastolic blood pressure
1
36.5
heel bone mineral density
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 8 VRAC subunit C
VGNC:11525
457009
Macaque
leucine rich repeat containing 8 VRAC subunit C
696086
Mouse
MGI:2140839
100604
Rat
RGD:1306585
289443
Dog
leucine rich repeat containing 8 VRAC subunit C
VGNC:42816
490168
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 8 VRAC subunit C
Macaque
leucine rich repeat containing 8 VRAC subunit C
Mouse
Rat
Dog
leucine rich repeat containing 8 VRAC subunit C
Publication Statistics
PubMed Score 6.41
PubMed score by year
PubTator Score 3.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title