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Tdark
LRRC73
Leucine-rich repeat-containing protein 73

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372441
  • ENSP00000361518
  • ENSG00000204052

Symbol
  • C6orf154
  • C6orf154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
cell type or tissue
0.6
cell line
0.5
histone modification site profile
0.47
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.05   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.05   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (29)
TBC1D5
Tbio
Novelty:  0.11547525
p_int:  0.999999956
p_ni:  4.4e-8
Data Source:  BioPlex
CYHR1
Tdark
Novelty:  0.04771996
p_int:  0.999791709
p_ni:  0.000206256
p_wrong:  0.000002035
Data Source:  BioPlex
KIAA1549
Tbio
Novelty:  0.01224835
p_int:  0.999393764
p_ni:  0.000606235
p_wrong:  1e-9
Data Source:  BioPlex
VPS26A
Tbio
Novelty:  0.01804654
p_int:  0.998459735
p_ni:  0.001540265
Score:  0.177
Data Source:  BioPlex,STRINGDB
VPS26B
Tdark
Novelty:  0.25702869
p_int:  0.997787568
p_ni:  0.002212432
Data Source:  BioPlex
DAZAP1
Tbio
Novelty:  0.04307077
p_int:  0.990392669
p_ni:  0.009607331
Data Source:  BioPlex
VPS35
Tbio
Novelty:  0.00729892
p_int:  0.977962451
p_ni:  0.02203622
p_wrong:  0.000001329
Data Source:  BioPlex
UBE4B
Tbio
Novelty:  0.01396546
p_int:  0.907843433
p_ni:  0.08996246
p_wrong:  0.002194107
Data Source:  BioPlex
CUEDC1
Tbio
Novelty:  0.14401061
p_int:  0.905707301
p_ni:  0.094292592
p_wrong:  1.07e-7
Data Source:  BioPlex
THAP12
Tbio
Family:  TF
Novelty:  0.21092098
p_int:  0.894768326
p_ni:  0.105230174
p_wrong:  0.0000015
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
toll-like receptor 2 measurement
1
1
1
56.3
glomerular filtration rate
1
2
2
48
mathematical ability
2
1
2
46
creatinine measurement
1
2
2
45.7
platelet count
2
1
2
42.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
toll-like receptor 2 measurement
1
56.3
glomerular filtration rate
2
48
mathematical ability
2
46
creatinine measurement
2
45.7
platelet count
2
42.1
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 73
VGNC:3372
737036
Mouse
MGI:2684934
224813
Rat
RGD:1561390
501101
Dog
leucine rich repeat containing 73
VGNC:42810
100684893
Horse
leucine rich repeat containing 73 [Source:HGNC Symbol;Acc:HGNC:21375]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 73
Mouse
Rat
Dog
leucine rich repeat containing 73
Horse
leucine rich repeat containing 73 [Source:HGNC Symbol;Acc:HGNC:21375]
Publication Statistics
PubMed Score 0.05
PubMed score by year
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Related Publications
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0 of 0
PMID
Year
Title