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Tdark
LRRC61
Leucine-rich repeat-containing protein 61

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323078
  • ENSP00000339047
  • ENSG00000127399
  • ENST00000359623
  • ENSP00000352642
  • ENST00000493307
  • ENSP00000420560

Symbol
  • HSPC295
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
histone modification site profile
0.71
small molecule perturbation
0.69
transcription factor
0.64
cell type or tissue
0.6


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.72   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
PLEKHA1
Tbio
Novelty:  0.03634462
p_int:  0.999999977
p_ni:  2.2e-8
Data Source:  BioPlex
FAM184A
Tdark
Novelty:  2.0967899
p_int:  0.99999982
p_ni:  1.8e-7
Data Source:  BioPlex
SIK2
Tchem
Family:  Kinase
Novelty:  0.01957886
p_int:  0.999995686
p_ni:  0.000004314
Data Source:  BioPlex
SNX1
Tbio
Novelty:  0.01267973
p_int:  0.99975081
p_ni:  0.000249189
Data Source:  BioPlex
VPS11
Tbio
Novelty:  0.00496411
p_int:  0.999408695
p_ni:  0.000591238
p_wrong:  6.7e-8
Data Source:  BioPlex
TGFBRAP1
Tbio
Novelty:  0.05996919
p_int:  0.996770564
p_ni:  0.003229435
p_wrong:  1e-9
Data Source:  BioPlex
CIP2A
Tbio
Novelty:  0.00992381
p_int:  0.994077115
p_ni:  0.005922885
Data Source:  BioPlex
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.991750955
p_ni:  0.008249045
Data Source:  BioPlex
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.989629878
p_ni:  0.010370122
Data Source:  BioPlex
PI4K2B
Tbio
Family:  Enzyme
Novelty:  0.19272599
p_int:  0.986655492
p_ni:  0.013344508
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemerin measurement
3
6
6
99
electroencephalogram measurement
1
1
0
5.5
46.4
blood protein measurement
1
1
1
34.6
platelet count
1
1
1
26.8
educational attainment
1
1
1
19.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chemerin measurement
6
99
electroencephalogram measurement
0
5.5
46.4
blood protein measurement
1
34.6
platelet count
1
26.8
educational attainment
1
19.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 61
VGNC:14040
100611946
Macaque
leucine rich repeat containing 61
704779
Mouse
MGI:2652848
243371
Rat
RGD:1561800
500111
Cow
leucine rich repeat containing 61
616659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 61
Macaque
leucine rich repeat containing 61
Mouse
Rat
Cow
leucine rich repeat containing 61
Publication Statistics
PubMed Score 0.72
PubMed score by year
PubTator Score 1.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title