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Tbio
LRRC6
Protein tilB homolog

Protein Summary
Description
May play a role in dynein arm assembly, hence essential for proper axoneme building for cilia motility. The protein encoded by this gene contains several leucine-rich repeat domains and appears to be involved in the motility of cilia. Defects in this gene are a cause of primary ciliary dyskinesia-19 (CILD19). Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 4, 11 and 22. [provided by RefSeq, Apr 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000519595
  • ENSP00000429791
  • ENSG00000129295
  • ENST00000620350
  • ENSP00000484634

Symbol
  • LRTP
  • TSLRP
  • LRTP
  • TSLRP
  • CILD19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.77
kinase perturbation
0.76
gene perturbation
0.73
tissue sample
0.61
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 194   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.21   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 194   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
SCRIB
Tbio
Novelty:  0.01099525
p_int:  0.998670653
p_ni:  0.001329347
Score:  0.237
Data Source:  BioPlex,STRINGDB
PHLPP2
Tbio
Family:  Enzyme
Novelty:  0.02479769
p_int:  0.998130496
p_ni:  5.99e-7
p_wrong:  0.001868905
Score:  0.562
Data Source:  BioPlex,STRINGDB
CHEK1
Tchem
Family:  Kinase
Novelty:  0.00066843
p_int:  0.968617994
p_ni:  0.031382004
p_wrong:  2e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
DHPS
Tchem
Family:  Enzyme
Novelty:  0.00776893
p_int:  0.799820297
p_ni:  0.200179699
p_wrong:  4e-9
Score:  0.206
Data Source:  BioPlex,STRINGDB
ZMYND10
Tbio
Novelty:  0.05524895
Score:  0.911
Data Source:  STRINGDB
DNAAF5
Tbio
Novelty:  0.27921814
Score:  0.844
Data Source:  STRINGDB
CCDC103
Tbio
Novelty:  0.07857649
Score:  0.84
Data Source:  STRINGDB
FAM187A
Tdark
Novelty:  0.07857649
Score:  0.84
Data Source:  STRINGDB
DNAAF2
Tbio
Novelty:  0.01254416
Score:  0.827
Data Source:  STRINGDB
DNAAF4
Tbio
Novelty:  0.01730685
Score:  0.813
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
1
2
2
65.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
educational attainment
2
65.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 6
VGNC:13175
464405
Macaque
leucine rich repeat containing 6
696651
Mouse
MGI:1859553
54562
Rat
RGD:1559937
299920
Dog
leucine rich repeat containing 6
VGNC:51775
475104
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 6
Macaque
leucine rich repeat containing 6
Mouse
Rat
Dog
leucine rich repeat containing 6
Publication Statistics
PubMed Score 16.21
PubMed score by year
PubTator Score 11.76
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title