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Tdark
LRRC56
Leucine-rich repeat-containing protein 56

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270115
  • ENSP00000270115
  • ENSG00000161328

Symbol
  • CILD39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.84
tissue sample
0.66
histone modification site profile
0.6
cell line
0.55
transcription factor
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.17   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
RANGRF
Tbio
Family:  Enzyme
Novelty:  0.02750539
p_int:  0.99999444
p_ni:  0.000004925
p_wrong:  6.35e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
METAP1D
Tbio
Family:  Enzyme
Novelty:  0.17714714
p_int:  0.999898234
p_ni:  5.51e-7
p_wrong:  0.000101215
Score:  0.359
Data Source:  BioPlex,STRINGDB
MAPK9
Tchem
Family:  Kinase
Novelty:  0.00267199
p_int:  0.998691467
p_ni:  0.001308523
p_wrong:  1e-8
Score:  0.2
Data Source:  BioPlex,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.996133871
p_ni:  0.003866129
Score:  0.31
Data Source:  BioPlex,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.941552785
p_ni:  0.058447215
Score:  0.189
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.917363825
p_ni:  0.082636175
Score:  0.163
Data Source:  BioPlex,STRINGDB
BHLHA9
Tbio
Family:  TF
Novelty:  0.05522751
Score:  0.732
Data Source:  STRINGDB
PKP3
Tbio
Novelty:  0.0269462
Score:  0.709
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.683
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
7
0
1.2
91.3
reticulocyte measurement
2
2
2
64.4
2
2
0
1.2
46.9
reticulocyte count
1
1
1
11.2
1
1
0
1.1
9.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
91.3
reticulocyte measurement
2
64.4
0
1.2
46.9
reticulocyte count
1
11.2
0
1.1
9.6
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 56
VGNC:11903
450924
Macaque
leucine rich repeat containing 56
698952
Mouse
MGI:1917802
70552
Rat
RGD:1311654
365389
Dog
leucine rich repeat containing 56
VGNC:42806
483404
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 56
Macaque
leucine rich repeat containing 56
Mouse
Rat
Dog
leucine rich repeat containing 56
Publication Statistics
PubMed Score 1.17
PubMed score by year
PubTator Score 1.00
PubTator score by year
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Related Publications
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PMID
Year
Title