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Tbio
LRRC55
Leucine-rich repeat-containing protein 55

Protein Summary
Description
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000497933
  • ENSP00000419542
  • ENSG00000183908
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.73
microRNA
0.66
cell line
0.62
tissue
0.48
protein domain
0.41


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.81   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
SLC9A1
Tchem
Family:  Transporter
Novelty:  0.00096678
p_int:  0.999994569
p_ni:  0.000005431
Data Source:  BioPlex
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
p_int:  0.999942169
p_ni:  0.000051617
p_wrong:  0.000006214
Data Source:  BioPlex
ATP13A2
Tbio
Family:  Transporter
Novelty:  0.00623191
p_int:  0.999649233
p_ni:  0.000350767
Data Source:  BioPlex
ENTPD4
Tbio
Family:  Enzyme
Novelty:  0.11023026
p_int:  0.999529663
p_ni:  0.000248331
p_wrong:  0.000222005
Data Source:  BioPlex
TMEM104
Tdark
p_int:  0.999439545
p_ni:  0.000356259
p_wrong:  0.000204196
Data Source:  BioPlex
SLC22A23
Tbio
Family:  Transporter
Novelty:  0.23405744
p_int:  0.99922526
p_ni:  0.00067839
p_wrong:  0.00009635
Data Source:  BioPlex
TMTC4
Tdark
Novelty:  0.53734704
p_int:  0.999007
p_ni:  0.000992997
p_wrong:  3e-9
Data Source:  BioPlex
FZD6
Tbio
Family:  GPCR
Novelty:  0.01425136
p_int:  0.998916588
p_ni:  0.000949704
p_wrong:  0.000133708
Data Source:  BioPlex
SFXN3
Tbio
Novelty:  0.18698456
p_int:  0.998854768
p_ni:  0.001145189
p_wrong:  4.3e-8
Data Source:  BioPlex
SLC35B2
Tbio
Family:  Transporter
Novelty:  0.01516638
p_int:  0.998700078
p_ni:  0.001294438
p_wrong:  0.000005484
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
1
1
0
6.9
41.5
gut microbiome measurement
2
1
2
27.9
body mass index
2
2
2
21
apolipoprotein A 1 measurement
1
1
1
8.5
heel bone mineral density
1
1
1
8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
brain measurement
0
6.9
41.5
gut microbiome measurement
2
27.9
body mass index
2
21
apolipoprotein A 1 measurement
1
8.5
heel bone mineral density
1
8
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 55
VGNC:53067
466584
Mouse
MGI:2685197
241528
Rat
RGD:1561726
311171
Dog
leucine rich repeat containing 55
VGNC:42805
483499
Horse
leucine rich repeat containing 55
VGNC:19786
100066848
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 55
Mouse
Rat
Dog
leucine rich repeat containing 55
Horse
leucine rich repeat containing 55
Publication Statistics
PubMed Score 4.81
PubMed score by year
PubTator Score 1.23
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title