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Tbio
LRRC52
Leucine-rich repeat-containing protein 52

Protein Summary
Description
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. KCNU1 channel auxiliary protein. May modulate KCNU1 gating properties.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294818
  • ENSP00000294818
  • ENSG00000162763
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.64
cell line
0.52
gene perturbation
0.5
chemical
0.43
phenotype
0.38


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.73   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.73   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PIGB
Tbio
Family:  Enzyme
Novelty:  0.05237713
p_int:  0.999927126
p_ni:  0.000067703
p_wrong:  0.000005171
Data Source:  BioPlex
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.999524938
p_ni:  0.000474807
p_wrong:  2.56e-7
Data Source:  BioPlex
LRRC3
Tdark
Novelty:  0.13484671
p_int:  0.9985828
p_ni:  0.00138479
p_wrong:  0.00003241
Data Source:  BioPlex
TMEM59L
Tbio
Novelty:  0.22745646
p_int:  0.998538822
p_ni:  0.00142073
p_wrong:  0.000040448
Data Source:  BioPlex
FAM3C
Tbio
Novelty:  0.04598347
p_int:  0.998135471
p_ni:  0.001864488
p_wrong:  4.1e-8
Data Source:  BioPlex
FAM69A
Tdark
Novelty:  0.35978059
p_int:  0.992438718
p_ni:  0.007551218
p_wrong:  0.000010064
Data Source:  BioPlex
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.98241206
p_ni:  0.016462367
p_wrong:  0.001125572
Data Source:  BioPlex
TPCN1
Tchem
Family:  IC
Novelty:  0.003844
p_int:  0.935659041
p_ni:  0.011959238
p_wrong:  0.05238172
Data Source:  BioPlex
CD151
Tbio
Novelty:  0.00295527
p_int:  0.895421423
p_ni:  0.007220608
p_wrong:  0.097357969
Data Source:  BioPlex
CTAGE5
Tbio
Novelty:  0.04516631
p_int:  0.864569474
p_ni:  0.135079439
p_wrong:  0.000351087
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
63.7
granulocyte count
1
1
1
5.3
electrocardiography
1
1
13
3.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
63.7
granulocyte count
1
5.3
electrocardiography
13
3.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 52
VGNC:1306
469563
Macaque
leucine rich repeat containing 52
696905
Mouse
MGI:1924118
240899
Rat
RGD:1312014
289199
Dog
leucine rich repeat containing 52
VGNC:42804
488671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 52
Macaque
leucine rich repeat containing 52
Mouse
Rat
Dog
leucine rich repeat containing 52
Publication Statistics
PubMed Score 5.73
PubMed score by year
PubTator Score 1.20
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title