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Tbio
LRRC4C
Leucine-rich repeat-containing protein 4C

Protein Summary
Description
May promote neurite outgrowth of developing thalamic neurons. NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278198
  • ENSP00000278198
  • ENSG00000148948
  • ENST00000527150
  • ENSP00000436976
  • ENST00000528697
  • ENSP00000437132
  • ENST00000530763
  • ENSP00000434761
  • ENST00000619527
  • ENSP00000480903

Symbol
  • KIAA1580
  • NGL1
  • NGL1
  • NGL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
0.86
transcription factor
0.62
cell line
0.59
disease
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.26   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (73)
LRRC4B
Tbio
Novelty:  0.21762254
p_int:  0.999999958
p_ni:  3.8e-8
p_wrong:  3e-9
Score:  0.281
Data Source:  BioPlex,STRINGDB
LRRC4
Tbio
Novelty:  0.03600857
p_int:  0.999997281
p_ni:  0.000002245
p_wrong:  4.74e-7
Score:  0.215
Data Source:  BioPlex,STRINGDB
VLDLR
Tbio
Novelty:  0.00352547
p_int:  0.999831726
p_ni:  0.000132693
p_wrong:  0.000035582
Score:  0.523
Data Source:  BioPlex,STRINGDB
SULF1
Tbio
Family:  Enzyme
Novelty:  0.00992209
p_int:  0.99922993
p_ni:  0.000357045
p_wrong:  0.000413026
Score:  0.157
Data Source:  BioPlex,STRINGDB
SULF2
Tbio
Family:  Enzyme
Novelty:  0.01536228
p_int:  0.999021346
p_ni:  0.000978646
p_wrong:  8e-9
Data Source:  BioPlex
DVL2
Tbio
Novelty:  0.00833084
p_int:  0.998771303
p_ni:  0.001228697
p_wrong:  1e-9
Score:  0.16
Data Source:  BioPlex,STRINGDB
SBF1
Tbio
Novelty:  0.01814482
p_int:  0.990640372
p_ni:  0.009359628
Data Source:  BioPlex
UBE2S
Tbio
Novelty:  0.00363304
p_int:  0.971352205
p_ni:  0.02864568
p_wrong:  0.000002115
Score:  0.224
Data Source:  BioPlex,STRINGDB
NCOA5
Tbio
Novelty:  0.09053523
p_int:  0.969683417
p_ni:  0.030316583
Score:  0.181
Data Source:  BioPlex,STRINGDB
DOLK
Tbio
Family:  Enzyme
Novelty:  0.00664639
p_int:  0.959761756
p_ni:  0.034218305
p_wrong:  0.006019939
Score:  0.153
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
3
3
4
14
95.9
Myopia
3
2
0
1.3
93.9
age at onset
1
1
0
14
83.3
smoking status measurement
2
2
2
63.3
risk-taking behaviour
2
2
2
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
refractive error measurement
4
14
95.9
Myopia
0
1.3
93.9
age at onset
0
14
83.3
smoking status measurement
2
63.3
risk-taking behaviour
2
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 4C
VGNC:12579
451129
Macaque
leucine rich repeat containing 4C
716620
Mouse
MGI:2442636
241568
Rat
RGD:1311013
311236
Dog
leucine rich repeat containing 4C
VGNC:42803
483417
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 4C
Macaque
leucine rich repeat containing 4C
Mouse
Rat
Dog
leucine rich repeat containing 4C
Publication Statistics
PubMed Score 14.26
PubMed score by year
PubTator Score 235.59
PubTator score by year
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Related Publications
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PMID
Year
Title