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Tbio
LRRC4B
Leucine-rich repeat-containing protein 4B

Protein Summary
Description
Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389201
  • ENSP00000373853
  • ENSG00000131409
  • ENST00000599957
  • ENSP00000471502

Symbol
  • LRIG4
  • HSM
  • LRIG4
  • NGL-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
cell type or tissue
0.72
gene perturbation
0.59
tissue sample
0.59
tissue
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.999999958
p_ni:  3.8e-8
p_wrong:  3e-9
Score:  0.281
Data Source:  BioPlex,STRINGDB
FAM19A5
Tdark
Novelty:  0.07792418
p_int:  0.999999571
p_ni:  4.29e-7
Score:  0.294
Data Source:  BioPlex,STRINGDB
FAM19A4
Tbio
Novelty:  0.04305684
p_int:  0.999983758
p_ni:  0.000015995
p_wrong:  2.46e-7
Score:  0.183
Data Source:  BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.999910735
p_ni:  0.000065642
p_wrong:  0.000023623
Data Source:  BioPlex
SNTG1
Tbio
Novelty:  0.05608114
p_int:  0.999564645
p_ni:  0.000361618
p_wrong:  0.000073737
Score:  0.17
Data Source:  BioPlex,STRINGDB
KLRG2
Tdark
Novelty:  1.19446694
p_int:  0.999250909
p_ni:  0.000734293
p_wrong:  0.000014798
Score:  0.201
Data Source:  BioPlex,STRINGDB
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.998285567
p_ni:  0.000793502
p_wrong:  0.000920931
Data Source:  BioPlex
PTPRS
Tchem
Family:  Enzyme
Novelty:  0.00587115
Score:  0.972
Data Source:  Reactome,STRINGDB
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
Score:  0.961
Data Source:  Reactome,STRINGDB
PTPRD
Tbio
Family:  Enzyme
Novelty:  0.01059407
Score:  0.955
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
1
1
0
1.4
73
2
1
0
1.4
58.4
smoking status measurement
2
1
2
36.5
body mass index
1
1
1
35
body height
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
primary biliary cirrhosis
0
1.4
73
0
1.4
58.4
smoking status measurement
2
36.5
body mass index
1
35
body height
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 4B
VGNC:11170
468964
Macaque
leucine rich repeat containing 4B
719338
Mouse
MGI:3027390
272381
Rat
RGD:1307121
308571
Dog
leucine rich repeat containing 4B
VGNC:42802
484361
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 4B
Macaque
leucine rich repeat containing 4B
Mouse
Rat
Dog
leucine rich repeat containing 4B
Publication Statistics
PubMed Score 5.46
PubMed score by year
PubTator Score 3.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title