Tbio LRRC4B Leucine-rich repeat-containing protein 4B

Protein Summary

Description

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

Uniprot Accession IDs

• Q9NT99
• Q3ZCQ4
• Q58F20

Gene Name

• LRRC4B

Ensembl ID

• ENST00000389201
• ENSP00000373853
• ENSG00000131409
• ENST00000599957
• ENSP00000471502

Symbol

• LRIG4
• HSM
• LRIG4
• NGL-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
cell type or tissue	0.72
gene perturbation	0.59
tissue sample	0.59
tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (61)

Explore Interacting Targets

1 – 10 of 61

• See Interactions on String-DB

LRRC4C

Tbio

Novelty:  0.06534005

p_int:  0.999999958

p_ni:  3.8e-8

p_wrong:  3e-9

Score:  0.281

Data Source:  BioPlex,STRINGDB

FAM19A5

Tdark

Novelty:  0.07792418

p_int:  0.999999571

p_ni:  4.29e-7

Score:  0.294

Data Source:  BioPlex,STRINGDB

FAM19A4

Tbio

Novelty:  0.04305684

p_int:  0.999983758

p_ni:  0.000015995

p_wrong:  2.46e-7

Score:  0.183

Data Source:  BioPlex,STRINGDB

TNFRSF10C

Tbio

Novelty:  0.0088942

p_int:  0.999910735

p_ni:  0.000065642

p_wrong:  0.000023623

Data Source:  BioPlex

SNTG1

Tbio

Novelty:  0.05608114

p_int:  0.999564645

p_ni:  0.000361618

p_wrong:  0.000073737

Score:  0.17

Data Source:  BioPlex,STRINGDB

KLRG2

Tdark

Novelty:  1.19446694

p_int:  0.999250909

p_ni:  0.000734293

p_wrong:  0.000014798

Score:  0.201

Data Source:  BioPlex,STRINGDB

LGALS8

Tchem

Novelty:  0.00623836

p_int:  0.998285567

p_ni:  0.000793502

p_wrong:  0.000920931

Data Source:  BioPlex

PTPRS

Tchem

Family:  Enzyme

Novelty:  0.00587115

Score:  0.972

Data Source:  Reactome,STRINGDB

PTPRF

Tchem

Family:  Enzyme

Novelty:  0.01017327

Score:  0.961

Data Source:  Reactome,STRINGDB

PTPRD

Tbio

Family:  Enzyme

Novelty:  0.01059407

Score:  0.955

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (4)

Reactome (3)

KEGG (1)

Neuronal System (R-HSA-112316)

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Find Similar Targets

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Neuronal System	398 targets	R-HSA-112316
Reactome	Protein-protein interactions at synapses	91 targets	R-HSA-6794362
Reactome	Receptor-type tyrosine-protein phosphatases	20 targets	R-HSA-388844

Name	Explore in Pharos	Explore in Source
Neuronal System	398 targets	R-HSA-112316
Protein-protein interactions at synapses	91 targets	R-HSA-6794362
Receptor-type tyrosine-protein phosphatases	20 targets	R-HSA-388844

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (1)

Components (6)

Processes (4)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
signaling receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
primary biliary cirrhosis	EFO_1001486	1	1	0	1.4	73
biliary liver cirrhosis	EFO_0004267	2	1	0	1.4	58.4
smoking status measurement	EFO_0006527	2	1	2		36.5
body mass index	EFO_0004340	1	1	1		35
body height	EFO_0004339	1	1	1		30.2

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
primary biliary cirrhosis	EFO_1001486	0	1.4	73
biliary liver cirrhosis	EFO_0004267	0	1.4	58.4
smoking status measurement	EFO_0006527	2		36.5
body mass index	EFO_0004340	1		35
body height	EFO_0004339	1		30.2

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Cell junction
Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Leucine-rich repeat
Membrane
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
biliary liver cirrhosis
body height
body mass index
electrocardiography
hematocrit
hemoglobin measurement
primary biliary cirrhosis
smoking status measurement
systolic blood pressure

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat containing 4B	VGNC:11170	468964
Macaque	leucine rich repeat containing 4B		719338
Mouse	leucine rich repeat containing 4B	MGI:3027390	272381
Rat	leucine rich repeat containing 4B	RGD:1307121	308571
Dog	leucine rich repeat containing 4B	VGNC:42802	484361

Species	Name	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat containing 4B
Macaque	leucine rich repeat containing 4B
Mouse	leucine rich repeat containing 4B
Rat	leucine rich repeat containing 4B
Dog	leucine rich repeat containing 4B

Publication Statistics

PubMed Score 5.46

PubMed score by year

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PubTator Score 3.95

PubTator score by year

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Related Publications

Text Mined References (4)

Items per page:

10

0 of 0

PMID	Year	Title