Tbio LRRC4B Leucine-rich repeat-containing protein 4B

Protein Summary

Description

Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity).

Uniprot Accession IDs

• Q9NT99
• Q3ZCQ4
• Q58F20

Gene Name

• LRRC4B

Ensembl ID

• ENST00000389201
• ENSP00000373853
• ENSG00000131409
• ENST00000599957
• ENSP00000471502

Symbol

• LRIG4
• HSM
• LRIG4
• NGL-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
cell type or tissue	0.72
gene perturbation	0.59
tissue sample	0.59
tissue	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 75   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.67   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0