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Tdark
LRRC49
Leucine-rich repeat-containing protein 49

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260382
  • ENSP00000260382
  • ENSG00000137821
  • ENST00000443425
  • ENSP00000414065
  • ENST00000544974
  • ENSP00000439600
  • ENST00000560369
  • ENSP00000453273

Symbol
  • PGs4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
transcription factor
0.61
tissue sample
0.59
transcription factor binding site profile
0.57
cell line
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.19   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
TTLL1
Tdark
Family:  Enzyme
Novelty:  0.09244899
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
NICN1
Tdark
Novelty:  0.32909597
p_int:  1
Score:  0.982
Data Source:  BioPlex,STRINGDB
C11orf49
Tdark
Novelty:  2.11371852
p_int:  1
Score:  0.914
Data Source:  BioPlex,STRINGDB
TPGS1
Tdark
Family:  Enzyme
Novelty:  0.38252921
p_int:  0.999999865
p_ni:  1.17e-7
p_wrong:  1.7e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
KIAA1841
Tdark
Novelty:  1.50148602
p_int:  0.999998146
p_ni:  4e-8
p_wrong:  0.000001814
Score:  0.851
Data Source:  BioPlex,STRINGDB
TBC1D19
Tdark
Novelty:  1.33062726
p_int:  0.99999377
p_ni:  4.5e-8
p_wrong:  0.000006185
Score:  0.843
Data Source:  BioPlex,STRINGDB
SMG8
Tdark
Novelty:  0.18080965
p_int:  0.99998614
p_ni:  0.00001386
Score:  0.558
Data Source:  BioPlex,STRINGDB
EIF3F
Tbio
Novelty:  0.0319772
p_int:  0.999968078
p_ni:  0.000031922
Score:  0.732
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.999957378
p_ni:  0.000041149
p_wrong:  0.000001473
Data Source:  BioPlex
TPGS2
Tdark
Family:  Enzyme
Novelty:  0.45018261
p_int:  0.999889611
p_ni:  0.000110389
Score:  0.981
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Carboxyterminal post-translational modifications of tubulin (R-HSA-8955332)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Carboxyterminal post-translational modifications of tubulin
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Carboxyterminal post-translational modifications of tubulin
Metabolism of proteins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
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Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 49
VGNC:13406
467718
Macaque
leucine rich repeat containing 49
696391
Mouse
MGI:2442689
102747
Rat
RGD:1309466
300763
Dog
leucine rich repeat containing 49
487626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 49
Macaque
leucine rich repeat containing 49
Mouse
Rat
Dog
leucine rich repeat containing 49
Publication Statistics
PubMed Score 5.19
PubMed score by year
PubTator Score 3.64
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title