You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
LRRC46
Leucine-rich repeat-containing protein 46

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269025
  • ENSP00000269025
  • ENSG00000141294
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.78
tissue sample
0.68
transcription factor binding site profile
0.61
tissue
0.55
cell line
0.49


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (57)
PACS2
Tbio
Novelty:  0.00887813
p_int:  0.99999999
p_ni:  3e-9
p_wrong:  7e-9
Score:  0.808
Data Source:  BioPlex,STRINGDB
WDR37
Tbio
Novelty:  0.1677975
p_int:  0.999999615
p_ni:  3.84e-7
Score:  0.223
Data Source:  BioPlex,STRINGDB
SIX4
Tbio
Family:  TF
Novelty:  0.01783726
p_int:  0.99999898
p_ni:  2.1e-8
p_wrong:  9.99e-7
Score:  0.303
Data Source:  BioPlex,STRINGDB
TFPT
Tbio
Novelty:  0.08573384
p_int:  0.999998294
p_ni:  0.000001698
p_wrong:  7e-9
Score:  0.173
Data Source:  BioPlex,STRINGDB
LRSAM1
Tbio
Family:  Enzyme
Novelty:  0.04083443
p_int:  0.99998381
p_ni:  0.000015225
p_wrong:  9.65e-7
Score:  0.198
Data Source:  BioPlex,STRINGDB
PLCD3
Tbio
Family:  Enzyme
Novelty:  0.04749421
p_int:  0.999980336
p_ni:  0.000019664
Score:  0.207
Data Source:  BioPlex,STRINGDB
TYK2
Tclin
Family:  Kinase
Novelty:  0.00237955
p_int:  0.997887943
p_ni:  0.002112057
Score:  0.21
Data Source:  BioPlex,STRINGDB
PITX2
Tbio
Family:  TF
Novelty:  0.00216568
p_int:  0.995451646
p_ni:  0.004397955
p_wrong:  0.0001504
Score:  0.188
Data Source:  BioPlex,STRINGDB
FZR1
Tbio
Novelty:  0.01599606
p_int:  0.994929996
p_ni:  0.00506972
p_wrong:  2.84e-7
Score:  0.184
Data Source:  BioPlex,STRINGDB
RRP7A
Tbio
Novelty:  0.11315285
p_int:  0.993893299
p_ni:  0.006106652
p_wrong:  5e-8
Score:  0.199
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
2
3
0
1.1
93.5
pulse pressure measurement
1
1
1
80.1
BMI-adjusted hip circumference
1
3
3
73
autoimmune thyroid disease
1
1
0
1.1
64
3
2
0
1.1
55.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
93.5
pulse pressure measurement
1
80.1
BMI-adjusted hip circumference
3
73
autoimmune thyroid disease
0
1.1
64
0
1.1
55.1
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 46
VGNC:51665
468430
Mouse
MGI:1916547
69297
Rat
RGD:1303311
287653
Dog
leucine rich repeat containing 46
480539
Horse
leucine rich repeat containing 46
VGNC:52407
100069167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 46
Mouse
Rat
Dog
leucine rich repeat containing 46
Horse
leucine rich repeat containing 46
Publication Statistics
PubMed Score 1.07
PubMed score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title