Pharos : Target Details

Tdark

Protein Summary

Uniprot Accession IDs

Gene Name

LRRC46

Ensembl ID

ENST00000269025
ENSP00000269025
ENSG00000141294

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.78

tissue sample	0.68

transcription factor binding site profile	0.61

tissue	0.55

cell line	0.49

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07 (req: < 5)

View Publications

Gene RIFs: 0 (req: <= 3)

Antibodies: 79 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.07 (req: >= 5)

Gene RIFs: 0 (req: > 3)

Antibodies: 79 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

View Data

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (57)

Explore Interacting Targets

1 – 10 of 57

See Interactions on String-DB

PACS2

Tbio

Novelty: 0.00887813

p_int: 0.99999999

p_ni: 3e-9

p_wrong: 7e-9

Score: 0.808

Data Source: BioPlex,STRINGDB

WDR37

Tbio

Novelty: 0.1677975

p_int: 0.999999615

p_ni: 3.84e-7

Score: 0.223

Data Source: BioPlex,STRINGDB

SIX4

Tbio

Family: TF

Novelty: 0.01783726

p_int: 0.99999898

p_ni: 2.1e-8

p_wrong: 9.99e-7

Score: 0.303

Data Source: BioPlex,STRINGDB

TFPT

Tbio

Novelty: 0.08573384

p_int: 0.999998294

p_ni: 0.000001698

p_wrong: 7e-9

Score: 0.173

Data Source: BioPlex,STRINGDB

LRSAM1

Tbio

Family: Enzyme

Novelty: 0.04083443

p_int: 0.99998381

p_ni: 0.000015225

p_wrong: 9.65e-7

Score: 0.198

Data Source: BioPlex,STRINGDB

PLCD3

Tbio

Family: Enzyme

Novelty: 0.04749421

p_int: 0.999980336

p_ni: 0.000019664

Score: 0.207

Data Source: BioPlex,STRINGDB

TYK2

Tclin

Family: Kinase

Novelty: 0.00237955

p_int: 0.997887943

p_ni: 0.002112057

Score: 0.21

Data Source: BioPlex,STRINGDB

PITX2

Tbio

Family: TF

Novelty: 0.00216568

p_int: 0.995451646

p_ni: 0.004397955

p_wrong: 0.0001504

Score: 0.188

Data Source: BioPlex,STRINGDB

FZR1

Tbio

Novelty: 0.01599606

p_int: 0.994929996

p_ni: 0.00506972

p_wrong: 2.84e-7

Score: 0.184

Data Source: BioPlex,STRINGDB

RRP7A

Tbio

Novelty: 0.11315285

p_int: 0.993893299

p_ni: 0.006106652

p_wrong: 5e-8

Score: 0.199

Data Source: BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (0)

No GO Terms found

Disease Associations ()

No disease associations found

GWAS Traits (13)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 13

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
hair color	EFO_0003924	2	3	0	1.1	93.5

pulse pressure measurement	EFO_0005763	1	1	1		80.1

BMI-adjusted hip circumference	EFO_0008039	1	3	3		73

autoimmune thyroid disease	EFO_0006812	1	1	0	1.1	64

asthma	EFO_0000270	3	2	0	1.1	55.1

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 5 of 13

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)
hair color	EFO_0003924	0	1.1	93.5

pulse pressure measurement	EFO_0005763	1		80.1

BMI-adjusted hip circumference	EFO_0008039	3		73

autoimmune thyroid disease	EFO_0006812	0	1.1	64

asthma	EFO_0000270	0	1.1	55.1

Beta Count

Odds Ratio

Find similar targets by:

UniProt Keyword

Find Similar Targets

GWAS Trait

Find Similar Targets

No Header	No Header
asthma

autoimmune thyroid disease

balding measurement

birth weight

BMI-adjusted hip circumference

body fat distribution

childhood onset asthma

hair color

hair colour measurement

lymphocyte count

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID
Chimp	leucine rich repeat containing 46	VGNC:51665	468430

Mouse	leucine rich repeat containing 46	MGI:1916547	69297

Rat	leucine rich repeat containing 46	RGD:1303311	287653

Dog	leucine rich repeat containing 46		480539

Horse	leucine rich repeat containing 46	VGNC:52407	100069167

Species	Name	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat containing 46

Mouse	leucine rich repeat containing 46

Rat	leucine rich repeat containing 46

Dog	leucine rich repeat containing 46

Horse	leucine rich repeat containing 46

Publication Statistics

PubMed Score 1.07

PubMed score by year

Related Publications

Text Mined References (6)

Items per page:

0 of 0

PMID	Year	Title

No Header	No Header
Coiled coil

Complete proteome

Leucine-rich repeat

Phosphoprotein

Reference proteome

Repeat