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Tdark
LRRC45
Leucine-rich repeat-containing protein 45

Protein Summary
Description
Component of the proteinaceous fiber-like linker between two centrioles, required for centrosome cohesion.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306688
  • ENSP00000306760
  • ENSG00000169683
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
transcription factor
0.66
histone modification site profile
0.64
cell line
0.6
tissue sample
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.09   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
ENTHD1
Tdark
Novelty:  5.29427978
p_int:  0.999998209
p_ni:  0.000001072
p_wrong:  7.19e-7
Data Source:  BioPlex
UPP1
Tchem
Family:  Enzyme
Novelty:  0.01384975
p_int:  0.985493913
p_ni:  0.000038121
p_wrong:  0.014467965
Score:  0.692
Data Source:  BioPlex,STRINGDB
BFSP1
Tbio
Novelty:  0.01519136
p_int:  0.835700015
p_ni:  9.85e-7
p_wrong:  0.164299
Data Source:  BioPlex
CNTLN
Tbio
Novelty:  0.0044959
Score:  0.804
Data Source:  STRINGDB
CROCC
Tbio
Novelty:  0.03718561
Score:  0.788
Data Source:  STRINGDB
FAM193B
Tdark
Novelty:  1.69956634
Score:  0.717
Data Source:  STRINGDB
KXD1
Tbio
Novelty:  0.32146379
Score:  0.705
Data Source:  STRINGDB
ERICH5
Tdark
Novelty:  5.57504212
Score:  0.697
Data Source:  STRINGDB
CEP250
Tbio
Novelty:  0.08014712
Score:  0.682
Data Source:  STRINGDB
WDR37
Tbio
Novelty:  0.1677975
Score:  0.584
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
1
1
76.4
BMI-adjusted hip circumference
2
5
6
67.4
birth weight
2
2
2
67.4
blood metabolite measurement
1
1
1
64.8
BMI-adjusted waist-hip ratio
2
3
3
62.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vital capacity
1
76.4
BMI-adjusted hip circumference
6
67.4
birth weight
2
67.4
blood metabolite measurement
1
64.8
BMI-adjusted waist-hip ratio
3
62.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 45
VGNC:9439
454981
Macaque
leucine rich repeat containing 45
715420
Mouse
MGI:2387183
217366
Rat
RGD:1590053
688318
Dog
leucine rich repeat containing 45
VGNC:42800
483375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 45
Macaque
leucine rich repeat containing 45
Mouse
Rat
Dog
leucine rich repeat containing 45
Publication Statistics
PubMed Score 4.09
PubMed score by year
PubTator Score 0.66
PubTator score by year
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Related Publications
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PMID
Year
Title