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Tdark
LRRC42
Leucine-rich repeat-containing protein 42

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319223
  • ENSP00000318185
  • ENSG00000116212
  • ENST00000371370
  • ENSP00000360421

Symbol
  • dJ167A19.4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
histone modification site profile
0.78
transcription factor perturbation
0.74
transcription factor
0.62
cellular component
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.76   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.76   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (6)
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999999825
p_ni:  1.75e-7
Score:  0.186
Data Source:  BioPlex,STRINGDB
KAT5
Tchem
Family:  Epigenetic
Novelty:  0.00368348
p_int:  0.996113043
p_ni:  0.00000438
p_wrong:  0.003882577
Score:  0.19
Data Source:  BioPlex,STRINGDB
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.990087789
p_ni:  0.009912211
Score:  0.211
Data Source:  BioPlex,STRINGDB
SUGT1
Tbio
Novelty:  0.1042721
p_int:  0.928006189
p_ni:  0.071993811
Score:  0.295
Data Source:  BioPlex,STRINGDB
MBD3
Tbio
Family:  TF
Novelty:  0.04513502
Score:  0.675
Data Source:  STRINGDB
GATAD2B
Tbio
Family:  TF
Novelty:  0.056775
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
1
1
81.1
hormone measurement
1
1
3
80.4
gut microbiome measurement
1
1
0
3.6
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
81.1
hormone measurement
3
80.4
gut microbiome measurement
0
3.6
24.5
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 42
VGNC:1304
456869
Macaque
leucine rich repeat containing 42
714839
Mouse
MGI:1925059
77809
Rat
RGD:1308919
298309
Dog
leucine rich repeat containing 42
VGNC:42799
489580
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 42
Macaque
leucine rich repeat containing 42
Mouse
Rat
Dog
leucine rich repeat containing 42
Publication Statistics
PubMed Score 0.76
PubMed score by year
PubTator Score 0.25
PubTator score by year
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Related Publications
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PMID
Year
Title