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Tdark
LRRC40
Leucine-rich repeat-containing protein 40

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370952
  • ENSP00000359990
  • ENSG00000066557

Symbol
  • dJ677H15.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
histone modification site profile
0.86
disease perturbation
0.79
protein complex
0.79
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.95   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.95   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (47)
CNPY3
Tbio
Novelty:  0.11473132
p_int:  0.999998123
p_ni:  0.000001877
Score:  0.952
Data Source:  BioPlex,STRINGDB
LRRC57
Tdark
Novelty:  5.85929893
p_int:  0.999951279
p_ni:  0.000048713
p_wrong:  7e-9
Score:  0.294
Data Source:  BioPlex,STRINGDB
AOPEP
Tbio
Family:  Enzyme
Novelty:  0.03344862
p_int:  0.999928093
p_ni:  0.000071907
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.999325143
p_ni:  0.00067432
p_wrong:  5.37e-7
Score:  0.325
Data Source:  BioPlex,STRINGDB
LUM
Tbio
Novelty:  0.00219939
p_int:  0.998988656
p_ni:  0.001011344
Score:  0.333
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.995598198
p_ni:  0.00435976
p_wrong:  0.000042042
Data Source:  BioPlex
PGK2
Tbio
Family:  Kinase
Novelty:  0.00832045
p_int:  0.993905029
p_ni:  0.006094849
p_wrong:  1.22e-7
Score:  0.16
Data Source:  BioPlex,STRINGDB
VASN
Tbio
Novelty:  0.05424159
p_int:  0.9886053
p_ni:  0.011394559
p_wrong:  1.41e-7
Data Source:  BioPlex
IQCF1
Tdark
Novelty:  0.78525464
p_int:  0.9807447
p_ni:  0.019181412
p_wrong:  0.000073888
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.973716741
p_ni:  0.026280693
p_wrong:  0.000002566
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
25.8
cognitive function measurement
1
1
1
19.6
educational attainment
1
1
1
18
mathematical ability
1
1
1
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
25.8
cognitive function measurement
1
19.6
educational attainment
1
18
mathematical ability
1
17.7
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 40
VGNC:11762
456936
Macaque
leucine rich repeat containing 40
702565
Mouse
MGI:1914394
67144
Rat
RGD:1562017
310946
Dog
leucine rich repeat containing 40 [Source:HGNC Symbol;Acc:HGNC:26004]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 40
Macaque
leucine rich repeat containing 40
Mouse
Rat
Dog
leucine rich repeat containing 40 [Source:HGNC Symbol;Acc:HGNC:26004]
Publication Statistics
PubMed Score 0.95
PubMed score by year
PubTator Score 0.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title