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Tbio
LRRC4
Leucine-rich repeat-containing protein 4

Protein Summary
Description
Synaptic adhesion protein. Regulates the formation of exitatory synapses through the recruitment of pre-and-postsynaptic proteins. Organize the lamina/pathway-specific differentiation of dendrites. Plays a important role for auditory synaptic responses. Involved in the suppression of glioma (By similarity). This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000249363
  • ENSP00000249363
  • ENSG00000128594

Symbol
  • BAG
  • NAG14
  • NGL-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
gene perturbation
0.61
tissue sample
0.56
kinase perturbation
0.54
PubMedID
0.53


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.19   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.19   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (56)
LRRC4C
Tbio
Novelty:  0.06534005
p_int:  0.999997281
p_ni:  0.000002245
p_wrong:  4.74e-7
Score:  0.215
Data Source:  BioPlex,STRINGDB
FAM114A2
Tdark
Novelty:  0.40545319
p_int:  0.999065625
p_ni:  0.000928367
p_wrong:  0.000006008
Score:  0.189
Data Source:  BioPlex,STRINGDB
TBCD
Tbio
Novelty:  0.01161221
p_int:  0.99089044
p_ni:  0.00910956
Score:  0.175
Data Source:  BioPlex,STRINGDB
XPO4
Tbio
Novelty:  0.01507446
p_int:  0.980036564
p_ni:  0.019963436
Score:  0.159
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.962255505
p_ni:  0.037744474
p_wrong:  2.2e-8
Data Source:  BioPlex
CIP2A
Tbio
Novelty:  0.00992381
p_int:  0.923716913
p_ni:  0.076283087
Data Source:  BioPlex
POMT2
Tbio
Family:  Enzyme
Novelty:  0.0251595
p_int:  0.8662559
p_ni:  0.1337441
Score:  0.177
Data Source:  BioPlex,STRINGDB
TNPO2
Tbio
Novelty:  0.10454262
p_int:  0.859192891
p_ni:  0.140807098
p_wrong:  1e-8
Data Source:  BioPlex
MID1
Tbio
Family:  Enzyme
Novelty:  0.02400169
p_int:  0.846194354
p_ni:  0.00636054
p_wrong:  0.147445106
Score:  0.197
Data Source:  BioPlex,STRINGDB
ITGB5
Tbio
Novelty:  0.01455909
p_int:  0.818482661
p_ni:  0.181499167
p_wrong:  0.000018173
Score:  0.181
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
87.7
mathematical ability
4
3
4
86
self reported educational attainment
2
3
3
82.3
intelligence
2
3
0
5.9
73.8
risk-taking behaviour
3
3
4
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
87.7
mathematical ability
4
86
self reported educational attainment
3
82.3
intelligence
0
5.9
73.8
risk-taking behaviour
4
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 4
VGNC:4417
739898
Macaque
leucine rich repeat containing 4
698610
Mouse
MGI:2182081
192198
Rat
RGD:1560026
641521
Dog
leucine rich repeat containing 4
VGNC:42797
607997
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 4
Macaque
leucine rich repeat containing 4
Mouse
Rat
Dog
leucine rich repeat containing 4
Publication Statistics
PubMed Score 36.19
PubMed score by year
PubTator Score 21.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title