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Tdark
LRRC39
Leucine-rich repeat-containing protein 39

Protein Summary
Description
Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342895
  • ENSP00000344470
  • ENSG00000122477
  • ENST00000370137
  • ENSP00000359156
  • ENST00000370138
  • ENSP00000359157
  • ENST00000620882
  • ENSP00000480740
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.68
tissue
0.62
cell type or tissue
0.58
tissue sample
0.5
cell line
0.48


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.83   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.83   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
NINL
Tbio
Novelty:  0.00726815
p_int:  0.999999875
p_ni:  1.24e-7
Score:  0.519
Data Source:  BioPlex,STRINGDB
MIPOL1
Tbio
Novelty:  0.2456
p_int:  0.999996062
p_ni:  0.000003283
p_wrong:  6.55e-7
Score:  0.519
Data Source:  BioPlex,STRINGDB
SUGT1
Tbio
Novelty:  0.1042721
p_int:  0.999893469
p_ni:  0.000106531
Score:  0.237
Data Source:  BioPlex,STRINGDB
CETN2
Tbio
Novelty:  0.00641301
p_int:  0.999881678
p_ni:  0.000118322
Score:  0.225
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
p_int:  0.989404537
p_ni:  0.010595463
Score:  0.196
Data Source:  BioPlex,STRINGDB
MYO5B
Tbio
Novelty:  0.01302142
p_int:  0.986449849
p_ni:  0.009023883
p_wrong:  0.004526269
Score:  0.291
Data Source:  BioPlex,STRINGDB
LIMA1
Tbio
Novelty:  0.02718476
p_int:  0.980078649
p_ni:  0.019921351
Score:  0.327
Data Source:  BioPlex,STRINGDB
CNNM4
Tbio
Novelty:  0.04199329
p_int:  0.931629823
p_ni:  0.068370177
Score:  0.3
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.915976711
p_ni:  0.084023289
Score:  0.197
Data Source:  BioPlex,STRINGDB
PTP4A1
Tchem
Family:  Enzyme
Novelty:  0.02863007
p_int:  0.840687323
p_ni:  0.159312674
p_wrong:  2e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 39
VGNC:11761
469393
Macaque
leucine rich repeat containing 39
711471
Mouse
MGI:1924557
109245
Rat
RGD:1585106
691307
Dog
leucine rich repeat containing 39
VGNC:54039
490141
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 39
Macaque
leucine rich repeat containing 39
Mouse
Rat
Dog
leucine rich repeat containing 39
Publication Statistics
PubMed Score 1.83
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title