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Tbio
LRRC32
Transforming growth factor beta activator LRRC32

Protein Summary
Description
Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260061
  • ENSP00000260061
  • ENSG00000137507
  • ENST00000404995
  • ENSP00000385766
  • ENST00000407242
  • ENSP00000384126

Symbol
  • D11S833E
  • GARP
  • D11S833E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
transcription factor
0.53
gene perturbation
0.52
biological process
0.51
cell line
0.5


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.71   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 280   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.71   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
ZDHHC6
Tbio
Family:  Enzyme
Novelty:  0.17384821
p_int:  0.999508707
p_ni:  0.000491293
Score:  0.167
Data Source:  BioPlex,STRINGDB
TGFB1
Tbio
Novelty:  0.0001299
p_int:  0.998888885
p_ni:  0.001111115
Score:  0.417
Data Source:  BioPlex,STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
p_int:  0.997710607
p_ni:  0.002289391
p_wrong:  3e-9
Score:  0.25
Data Source:  BioPlex,STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
p_int:  0.994813414
p_ni:  0.004047712
p_wrong:  0.001138874
Score:  0.179
Data Source:  BioPlex,STRINGDB
SMPD2
Tchem
Family:  Enzyme
Novelty:  0.00375744
p_int:  0.987782383
p_ni:  0.012217438
p_wrong:  1.79e-7
Score:  0.185
Data Source:  BioPlex,STRINGDB
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.980895034
p_ni:  0.019061761
p_wrong:  0.000043205
Score:  0.163
Data Source:  BioPlex,STRINGDB
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.974486275
p_ni:  0.009508865
p_wrong:  0.01600486
Score:  0.185
Data Source:  BioPlex,STRINGDB
STK11IP
Tdark
Family:  Enzyme
Novelty:  0.2856954
p_int:  0.939918884
p_ni:  0.060081116
Score:  0.188
Data Source:  BioPlex,STRINGDB
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.844799312
p_ni:  0.155200688
Data Source:  BioPlex
LEMD3
Tbio
Novelty:  0.00579701
p_int:  0.843323256
p_ni:  0.156676744
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (36)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
8
0
1.1
98.7
eosinophil count
5
5
6
97.8
6
6
5
1.1
97.6
childhood onset asthma
3
4
0
1.3
96.3
4
4
0
1.1
95.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
98.7
eosinophil count
6
97.8
5
1.1
97.6
childhood onset asthma
0
1.3
96.3
0
1.1
95.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 32
VGNC:53066
451434
Macaque
leucine rich repeat containing 32
697438
Mouse
MGI:93882
434215
Rat
RGD:1309087
293135
Dog
leucine rich repeat containing 32 [Source:HGNC Symbol;Acc:HGNC:4161]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 32
Macaque
leucine rich repeat containing 32
Mouse
Rat
Dog
leucine rich repeat containing 32 [Source:HGNC Symbol;Acc:HGNC:4161]
Publication Statistics
PubMed Score 51.71
PubMed score by year
PubTator Score 67.85
PubTator score by year
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Related Publications
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PMID
Year
Title