Tbio LRRC32 Transforming growth factor beta activator LRRC32

Protein Summary

Description

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19750484, PubMed:19651619, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19750484, PubMed:19651619). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity). This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14392
• Q86V06

Gene Name

• LRRC32

Ensembl ID

• ENST00000260061
• ENSP00000260061
• ENSG00000137507
• ENST00000404995
• ENSP00000385766
• ENST00000407242
• ENSP00000384126

Symbol

• D11S833E
• GARP
• D11S833E

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
tissue sample	0.71
transcription factor	0.53
gene perturbation	0.52
biological process	0.51
cell line	0.5

Protein Classes

PANTHER Classes

Protein / Receptor / Transforming Growth Factor Beta Activator Lrrc32

Protein / Extracellular Matrix Protein / Transforming Growth Factor Beta Activator Lrrc32

DTO Classes

Protein / Receptor / Leucine-rich Repeat-containing Protein 32

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.63   (req: < 5)

Gene RIFs: 39   (req: <= 3)

Antibodies: 280   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.63   (req: >= 5)

Gene RIFs: 39   (req: > 3)

Antibodies: 280   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0