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Tdark
LRRC3
Leucine-rich repeat-containing protein 3

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291592
  • ENSP00000291592
  • ENSG00000160233

Symbol
  • C21orf102
  • LRRC3A
  • LRRC3DN
  • C21orf30
  • C21orf102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.65
cell type or tissue
0.49
cell line
0.46
tissue
0.44
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
CHST6
Tbio
Family:  Enzyme
Novelty:  0.01917947
p_int:  0.999733075
p_ni:  0.000266925
Data Source:  BioPlex
NCEH1
Tchem
Family:  Enzyme
Novelty:  0.01528589
p_int:  0.999110105
p_ni:  0.000863908
p_wrong:  0.000025987
Data Source:  BioPlex
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.998825453
p_ni:  0.001134959
p_wrong:  0.000039589
Data Source:  BioPlex
LRRC52
Tbio
Family:  IC
Novelty:  0.15407898
p_int:  0.9985828
p_ni:  0.00138479
p_wrong:  0.00003241
Data Source:  BioPlex
SCNN1D
Tbio
Family:  IC
Novelty:  0.06191685
p_int:  0.974907735
p_ni:  0.019007983
p_wrong:  0.006084282
Score:  0.17
Data Source:  BioPlex,STRINGDB
ADAM2
Tbio
Family:  Enzyme
Novelty:  0.00586482
p_int:  0.929340144
p_ni:  0.00215235
p_wrong:  0.068507506
Score:  0.228
Data Source:  BioPlex,STRINGDB
ADAM21
Tdark
Family:  Enzyme
Novelty:  0.16068055
p_int:  0.929340144
p_ni:  0.00215235
p_wrong:  0.068507506
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.886836464
p_ni:  0.0008643
p_wrong:  0.112299236
Data Source:  BioPlex
GALNT13
Tbio
Family:  Enzyme
Novelty:  0.12592259
p_int:  0.869687857
p_ni:  0.001717032
p_wrong:  0.12859511
Score:  0.252
Data Source:  BioPlex,STRINGDB
ADAM17
Tchem
Family:  Enzyme
Novelty:  0.00121971
p_int:  0.820850728
p_ni:  0.001593841
p_wrong:  0.17755543
Score:  0.31
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
4.2
63.7
balding measurement
1
1
1
62.5
1
1
1
14.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4.2
63.7
balding measurement
1
62.5
1
14.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 3
474135
Mouse
MGI:2447899
237387
Rat
RGD:628861
246773
Dog
leucine rich repeat containing 3
VGNC:53033
487800
Horse
leucine rich repeat containing 3
VGNC:19775
100050523
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 3
Mouse
Rat
Dog
leucine rich repeat containing 3
Horse
leucine rich repeat containing 3
Publication Statistics
PubMed Score 3.92
PubMed score by year
PubTator Score 2.46
PubTator score by year
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Related Publications
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PMID
Year
Title