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Tdark
LRRC28
Leucine-rich repeat-containing protein 28

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301981
  • ENSP00000304923
  • ENSG00000168904
  • ENST00000447360
  • ENSP00000404520
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.84
transcription factor binding site profile
0.77
kinase perturbation
0.76
tissue sample
0.66
cell type or tissue
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.81   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.81   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999999998
p_ni:  2e-9
Score:  0.223
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999970779
p_ni:  0.000029221
Score:  0.173
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.99572088
p_ni:  0.00427912
Data Source:  BioPlex
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.918806566
p_ni:  0.081193434
Data Source:  BioPlex
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
p_int:  0.881797199
p_ni:  0.000579306
p_wrong:  0.117623495
Score:  0.228
Data Source:  BioPlex,STRINGDB
FAM217B
Tdark
Novelty:  4.03122155
Score:  0.779
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
ASB8
Tdark
Novelty:  0.44680949
Score:  0.683
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
1
4
87.3
total cholesterol measurement
1
1
2
79.7
triglyceride measurement
2
1
3
74.3
hematocrit
1
1
1
10.9
hemoglobin measurement
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
87.3
total cholesterol measurement
2
79.7
triglyceride measurement
3
74.3
hematocrit
1
10.9
hemoglobin measurement
1
10.7
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 28
740096
Macaque
leucine rich repeat containing 28
708649
Mouse
MGI:1915689
67867
Rat
RGD:1307209
361588
Dog
leucine rich repeat containing 28
VGNC:42794
479023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 28
Macaque
leucine rich repeat containing 28
Mouse
Rat
Dog
leucine rich repeat containing 28
Publication Statistics
PubMed Score 1.81
PubMed score by year
PubTator Score 1.48
PubTator score by year
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Related Publications
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PMID
Year
Title