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Tdark
LRRC27
Leucine-rich repeat-containing protein 27

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344079
  • ENSP00000342641
  • ENSG00000148814
  • ENST00000368612
  • ENSP00000357601
  • ENST00000368613
  • ENSP00000357602
  • ENST00000368614
  • ENSP00000357603
  • ENST00000625755
  • ENSP00000486582

Symbol
  • KIAA1674
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.75
transcription factor binding site profile
0.73
cellular component
0.63
histone modification site profile
0.59
microRNA
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.59   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 9   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.59   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 9   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
HMOX1
Tchem
Family:  Enzyme
Novelty:  0.00013981
p_int:  0.999898242
p_ni:  0.000101758
Score:  0.169
Data Source:  BioPlex,STRINGDB
MCM8
Tbio
Family:  Enzyme
Novelty:  0.02602136
p_int:  0.985223541
p_ni:  0.014776385
p_wrong:  7.4e-8
Score:  0.194
Data Source:  BioPlex,STRINGDB
SCRIB
Tbio
Novelty:  0.01099525
p_int:  0.980283052
p_ni:  0.019716948
Score:  0.165
Data Source:  BioPlex,STRINGDB
IFT52
Tbio
Novelty:  0.04183122
p_int:  0.946987752
p_ni:  0.036617197
p_wrong:  0.016395051
Score:  0.188
Data Source:  BioPlex,STRINGDB
LRRC40
Tdark
Novelty:  2.43377466
p_int:  0.922406452
p_ni:  0.077354568
p_wrong:  0.00023898
Score:  0.171
Data Source:  BioPlex,STRINGDB
POLA2
Tbio
Family:  Enzyme
Novelty:  0.07371844
p_int:  0.857053108
p_ni:  0.142946657
p_wrong:  2.35e-7
Score:  0.18
Data Source:  BioPlex,STRINGDB
WDR19
Tbio
Novelty:  0.037197
p_int:  0.822416797
p_ni:  0.177583203
Score:  0.229
Data Source:  BioPlex,STRINGDB
BBS7
Tbio
Novelty:  0.03611111
p_int:  0.819406896
p_ni:  0.180593104
Score:  0.156
Data Source:  BioPlex,STRINGDB
PJA1
Tbio
Family:  Enzyme
Novelty:  0.06148437
p_int:  0.794691532
p_ni:  0.205308468
Score:  0.161
Data Source:  BioPlex,STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
Score:  0.813
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
2
2
2
76.7
risky sexual behaviour measurement
1
1
1
44.2
risk-taking behaviour
1
1
1
31.4
smoking status measurement
1
1
1
24.5
pneumococcal meningitis
1
1
0
4.3
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at first sexual intercourse measurement
2
76.7
risky sexual behaviour measurement
1
44.2
risk-taking behaviour
1
31.4
smoking status measurement
1
24.5
pneumococcal meningitis
0
4.3
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 27
VGNC:12368
450836
Macaque
leucine rich repeat containing 27
700131
Mouse
MGI:1923862
76612
Rat
RGD:1559981
499281
Dog
leucine rich repeat containing 27
VGNC:42793
607648
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 27
Macaque
leucine rich repeat containing 27
Mouse
Rat
Dog
leucine rich repeat containing 27
Publication Statistics
PubMed Score 1.59
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title