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Tdark
LRRC24
Leucine-rich repeat-containing protein 24

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000529415
  • ENSP00000434849
  • ENSG00000254402

Symbol
  • LRRC14OS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
tissue sample
0.67
cell line
0.66
gene perturbation
0.56
transcription factor
0.52


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
GAA
Tclin
Family:  Enzyme
Novelty:  0.0063246
p_int:  0.999281612
p_ni:  0.000245372
p_wrong:  0.000473016
Score:  0.223
Data Source:  BioPlex,STRINGDB
MAN1A1
Tbio
Family:  Enzyme
Novelty:  0.00645679
p_int:  0.998706143
p_ni:  0.001241238
p_wrong:  0.000052619
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.961076034
p_ni:  0.017811394
p_wrong:  0.021112572
Data Source:  BioPlex
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.911708001
p_ni:  0.00312887
p_wrong:  0.085163129
Score:  0.187
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.764373919
p_ni:  0.000908229
p_wrong:  0.234717852
Data Source:  BioPlex
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.685
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.685
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.685
Data Source:  STRINGDB
ROBO2
Tbio
Novelty:  0.00757203
Score:  0.631
Data Source:  STRINGDB
LRRC14
Tdark
Novelty:  0.67398865
Score:  0.605
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
intelligence
5
6
2
5.8
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
intelligence
2
5.8
82
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 24
VGNC:853
104007794
Macaque
chromosome 8 open reading frame, human C8orf82
703702
Mouse
MGI:3605040
378937
Rat
RGD:1308720
362945
Dog
leucine rich repeat containing 24
VGNC:42790
609936
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 24
Macaque
chromosome 8 open reading frame, human C8orf82
Mouse
Rat
Dog
leucine rich repeat containing 24
Publication Statistics
PubMed Score 0.29
PubMed score by year
PubTator Score 0.20
PubTator score by year
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Related Publications
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PMID
Year
Title