Tdark LRRC24 Leucine-rich repeat-containing protein 24

Protein Summary

Uniprot Accession IDs

• Q50LG9

Gene Name

• LRRC24

Ensembl ID

• ENST00000529415
• ENSP00000434849
• ENSG00000254402

Symbol

• LRRC14OS

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
tissue sample	0.67
cell line	0.66
gene perturbation	0.56
transcription factor	0.52

Protein Classes

PANTHER Classes

Protein / Receptor / Leucine-rich Repeat-containing Protein 24

Protein / Extracellular Matrix Protein / Leucine-rich Repeat-containing Protein 24

DTO Classes

Protein / Receptor / Leucine-rich Repeat-containing Protein 24

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 50   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.29   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (32)

Explore Interacting Targets

1 – 10 of 32

• See Interactions on String-DB

GAA

Tclin

Family:  Enzyme

Novelty:  0.0063246

p_int:  0.999281612

p_ni:  0.000245372

p_wrong:  0.000473016

Score:  0.223

Data Source:  BioPlex,STRINGDB

MAN1A1

Tbio

Family:  Enzyme

Novelty:  0.00645679

p_int:  0.998706143

p_ni:  0.001241238

p_wrong:  0.000052619

Data Source:  BioPlex

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.961076034

p_ni:  0.017811394

p_wrong:  0.021112572

Data Source:  BioPlex

HLA-E

Tbio

Novelty:  0.00216583

p_int:  0.911708001

p_ni:  0.00312887

p_wrong:  0.085163129

Score:  0.187

Data Source:  BioPlex,STRINGDB

HFE

Tbio

Novelty:  0.00042077

p_int:  0.764373919

p_ni:  0.000908229

p_wrong:  0.234717852

Data Source:  BioPlex

ADGRL1

Tbio

Family:  GPCR

Novelty:  0.00957739

Score:  0.685

Data Source:  STRINGDB

ADGRL2

Tbio

Family:  GPCR

Novelty:  0.00985539

Score:  0.685

Data Source:  STRINGDB

ADGRL3

Tbio

Family:  GPCR

Novelty:  0.00268343

Score:  0.685

Data Source:  STRINGDB

ROBO2

Tbio

Novelty:  0.00757203

Score:  0.631

Data Source:  STRINGDB

LRRC14

Tdark

Novelty:  0.67398865

Score:  0.605

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (4)

Components (3)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
extracellular matrix	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
extracellular space	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
integral component of membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (17)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	4	4	4		93.4
sex hormone-binding globulin measurement	EFO_0004696	6	2	6		90.7
self reported educational attainment	EFO_0004784	5	3	4	5.9	90.6
red blood cell distribution width	EFO_0005192	2	2	2		83
intelligence	EFO_0004337	5	6	2	5.8	82

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 17

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	4		93.4
sex hormone-binding globulin measurement	EFO_0004696	6		90.7
self reported educational attainment	EFO_0004784	4	5.9	90.6
red blood cell distribution width	EFO_0005192	2		83
intelligence	EFO_0004337	2	5.8	82

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Complete proteome
Disulfide bond
Glycoprotein
Immunoglobulin domain
Leucine-rich repeat
Membrane
Reference proteome
Repeat
Signal
Transmembrane

GWAS Trait Find Similar Targets

No Header	No Header
age at first birth measurement
alkaline phosphatase measurement
biological sex
blood metabolite measurement
cognitive function measurement
household income
intelligence
mathematical ability
mean corpuscular hemoglobin concentration
mean reticulocyte volume

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat containing 24	VGNC:853	104007794
Macaque	chromosome 8 open reading frame, human C8orf82		703702
Mouse	leucine rich repeat containing 24	MGI:3605040	378937
Rat	leucine rich repeat containing 24	RGD:1308720	362945
Dog	leucine rich repeat containing 24	VGNC:42790	609936

Species	Name	OMA	EggNOG	Inparanoid
Chimp	leucine rich repeat containing 24
Macaque	chromosome 8 open reading frame, human C8orf82
Mouse	leucine rich repeat containing 24
Rat	leucine rich repeat containing 24
Dog	leucine rich repeat containing 24

Publication Statistics

PubMed Score 0.29

PubMed score by year

Reset Zoom

PubTator Score 0.20

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (6)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title