LRRC14
Leucine-rich repeat-containing protein 14
Protein Summary
Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
- ENST00000292524
- ENSP00000292524
- ENSG00000160959
- ENST00000529022
- ENSP00000434768
- KIAA0014
- LRRC14A
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.72 | ||
kinase perturbation | 0.71 | ||
disease perturbation | 0.68 | ||
cellular component | 0.63 | ||
cell type or tissue | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.74 (req: < 5)
Gene RIFs: 2 (req: <= 3)
Antibodies: 56 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.74 (req: >= 5)
Gene RIFs: 2 (req: > 3)
Antibodies: 56 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (25)
CUL2
Novelty: 0.00512916
p_int: 0.999999992
p_ni: 8e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (17)
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 4 | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 2 | 6 | 90.7 | |||||
self reported educational attainment | 5 | 3 | 4 | 5.9 | 90.6 | ||||
red blood cell distribution width | 2 | 2 | 2 | 83 | |||||
intelligence | 5 | 6 | 2 | 5.8 | 82 | ||||
Items per page:
1 – 5 of 17
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mathematical ability | 4 | 93.4 | |||||
sex hormone-binding globulin measurement | 6 | 90.7 | |||||
self reported educational attainment | 4 | 5.9 | 90.6 | ||||
red blood cell distribution width | 2 | 83 | |||||
intelligence | 2 | 5.8 | 82 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | leucine rich repeat containing 14 | VGNC:13174 | 472902 | |||||
Mouse | MGI:2445060 | 223664 | ||||||
Rat | RGD:1560202 | 500900 | ||||||
Dog | leucine rich repeat containing 14 | VGNC:42784 | 482102 | |||||
Horse | leucine rich repeat containing 14 | VGNC:19767 | 100063224 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | leucine rich repeat containing 14 | |||||
Mouse | ||||||
Rat | ||||||
Dog | leucine rich repeat containing 14 | |||||
Horse | leucine rich repeat containing 14 | |||||
Publication Statistics
PubMed Score 1.74
PubMed score by year
PubTator Score 0.33
PubTator score by year
Related Publications
Text Mined References (6)
GeneRif Annotations (2)
Items per page:
0 of 0
PMID | Year | Title |
|---|