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Tdark
LRRC14
Leucine-rich repeat-containing protein 14

Protein Summary
Description
Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB. This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292524
  • ENSP00000292524
  • ENSG00000160959
  • ENST00000529022
  • ENSP00000434768

Symbol
  • KIAA0014
  • LRRC14A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.72
kinase perturbation
0.71
disease perturbation
0.68
cellular component
0.63
cell type or tissue
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 56   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.74   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 56   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999999992
p_ni:  8e-9
Score:  0.176
Data Source:  BioPlex,STRINGDB
SURF2
Tdark
Novelty:  0.10662558
Score:  0.731
Data Source:  STRINGDB
PDCD10
Tbio
Novelty:  0.00683934
Score:  0.631
Data Source:  STRINGDB
PPP1R16A
Tdark
Family:  Enzyme
Novelty:  0.1958289
Score:  0.619
Data Source:  STRINGDB
PREPL
Tchem
Family:  Enzyme
Novelty:  0.02310586
Score:  0.612
Data Source:  STRINGDB
LRRC24
Tdark
Novelty:  2.61911627
Score:  0.605
Data Source:  STRINGDB
CAMKMT
Tbio
Family:  Enzyme
Novelty:  0.00382649
Score:  0.603
Data Source:  STRINGDB
GLI4
Tbio
Family:  TF
Novelty:  0.15339473
Score:  0.585
Data Source:  STRINGDB
ZNF707
Tdark
Family:  TF
Novelty:  1.42194815
Score:  0.578
Data Source:  STRINGDB
DXO
Tbio
Family:  Enzyme
Novelty:  0.08260087
Score:  0.536
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
93.4
sex hormone-binding globulin measurement
6
2
6
90.7
self reported educational attainment
5
3
4
5.9
90.6
red blood cell distribution width
2
2
2
83
intelligence
5
6
2
5.8
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
93.4
sex hormone-binding globulin measurement
6
90.7
self reported educational attainment
4
5.9
90.6
red blood cell distribution width
2
83
intelligence
2
5.8
82
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 14
VGNC:13174
472902
Mouse
MGI:2445060
223664
Rat
RGD:1560202
500900
Dog
leucine rich repeat containing 14
VGNC:42784
482102
Horse
leucine rich repeat containing 14
VGNC:19767
100063224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat containing 14
Mouse
Rat
Dog
leucine rich repeat containing 14
Horse
leucine rich repeat containing 14
Publication Statistics
PubMed Score 1.74
PubMed score by year
PubTator Score 0.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title