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Tbio
LRP4
Low-density lipoprotein receptor-related protein 4

Protein Summary
Description
Mediates SOST-dependent inhibition of bone formation. Functions as a specific facilitator of SOST-mediated inhibition of Wnt signaling. Plays a key role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between motor neuron and skeletal muscle. Directly binds AGRIN and recruits it to the MUSK signaling complex. Mediates the AGRIN-induced phosphorylation of MUSK, the kinase of the complex. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Alternatively, may be involved in the negative regulation of the canonical Wnt signaling pathway, being able to antagonize the LRP6-mediated activation of this pathway. More generally, has been proposed to function as a cell surface endocytic receptor binding and internalizing extracellular ligands for degradation by lysosomes. May play an essential role in the process ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000378623
  • ENSP00000367888
  • ENSG00000134569

Symbol
  • KIAA0816
  • LRP10
  • MEGF7
  • CLSS
  • CMS17
  • LRP-4
  • LRP10
  • MEGF7
  • SOST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
biological process
0.88
co-expressed gene
0.79
transcription factor perturbation
0.74
PubMedID
0.69


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.33   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 318   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.33   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 318   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (55)
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999999025
p_ni:  9.75e-7
Data Source:  BioPlex
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.999995577
p_ni:  0.000004422
p_wrong:  2e-9
Data Source:  BioPlex
LRPAP1
Tbio
Novelty:  0.00214194
p_int:  0.999991811
p_ni:  0.000008188
p_wrong:  1e-9
Score:  0.408
Data Source:  BioPlex,STRINGDB
ZNF354C
Tdark
Family:  TF
Novelty:  0.09978239
p_int:  0.99999048
p_ni:  0.000009518
p_wrong:  2e-9
Data Source:  BioPlex
GDF10
Tbio
Novelty:  0.02874585
p_int:  0.999965046
p_ni:  0.000034954
Score:  0.19
Data Source:  BioPlex,STRINGDB
ZNF331
Tbio
Family:  TF
Novelty:  0.05976217
p_int:  0.999948238
p_ni:  0.000051762
Data Source:  BioPlex
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.99989162
p_ni:  0.00010838
Data Source:  BioPlex
BEND7
Tdark
Novelty:  0.5500966
p_int:  0.99971974
p_ni:  0.00028026
Score:  0.295
Data Source:  BioPlex,STRINGDB
ZNF398
Tbio
Family:  TF
Novelty:  0.01578856
p_int:  0.999593958
p_ni:  0.000406037
p_wrong:  4e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
ZNF224
Tbio
Family:  TF
Novelty:  0.05381083
p_int:  0.9995456
p_ni:  0.000454399
p_wrong:  1e-9
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96.8
2
1
1
1.9
89.2
bone density
2
3
3
88.8
systolic blood pressure
1
1
1
76.8
blood protein measurement
3
2
3
67.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96.8
1
1.9
89.2
bone density
3
88.8
systolic blood pressure
1
76.8
blood protein measurement
3
67.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 4
VGNC:3110
451161
Macaque
LDL receptor related protein 4
714038
Mouse
MGI:2442252
228357
Rat
RGD:619731
83469
Dog
LDL receptor related protein 4
VGNC:42777
483628
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LDL receptor related protein 4
Macaque
LDL receptor related protein 4
Mouse
Rat
Dog
LDL receptor related protein 4
Publication Statistics
PubMed Score 103.33
PubMed score by year
PubTator Score 122.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title