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Tbio
LRP1B
Low-density lipoprotein receptor-related protein 1B

Protein Summary
Description
Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis. This gene encodes a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389484
  • ENSP00000374135
  • ENSG00000168702

Symbol
  • LRPDIT
  • LRP-1B
  • LRPDIT
  • LRP-DIT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
trait
1
gene perturbation
0.98
virus perturbation
0.68
interacting protein
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.59   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.59   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (92)
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.99999363
p_ni:  0.000006369
Data Source:  BioPlex
LRPAP1
Tbio
Novelty:  0.00214194
p_int:  0.99999243
p_ni:  0.000007566
p_wrong:  3e-9
Score:  0.509
Data Source:  BioPlex,STRINGDB
ZNF408
Tbio
Family:  TF
Novelty:  0.10649477
p_int:  0.999981887
p_ni:  0.000018113
Data Source:  BioPlex
ANKRD36B
Tdark
Novelty:  2.44907149
p_int:  0.999903308
p_ni:  0.000096692
Data Source:  BioPlex
ZNF224
Tbio
Family:  TF
Novelty:  0.05381083
p_int:  0.999832349
p_ni:  0.000167651
Score:  0.158
Data Source:  BioPlex,STRINGDB
FOXD4L6
Tdark
Family:  TF
Novelty:  9.78461538
p_int:  0.999816357
p_ni:  0.000183642
p_wrong:  1e-9
Data Source:  BioPlex
ZNF331
Tbio
Family:  TF
Novelty:  0.05976217
p_int:  0.999728942
p_ni:  0.000271058
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.999393249
p_ni:  0.000606749
p_wrong:  2e-9
Data Source:  BioPlex
FEZF1
Tbio
Family:  TF
Novelty:  0.01942826
p_int:  0.998601827
p_ni:  0.001398173
Data Source:  BioPlex
ZNF563
Tdark
Family:  TF
Novelty:  5.34386694
p_int:  0.998590629
p_ni:  0.001409371
Score:  0.167
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
7
6
1
77.9
comparative body size at age 10, self-reported
1
1
1
70.2
household income
1
2
2
66.6
body mass index
5
4
6
66.3
1
2
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
1
77.9
comparative body size at age 10, self-reported
1
70.2
household income
2
66.6
body mass index
6
66.3
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
LDL receptor related protein 1B
721791
Mouse
MGI:2151136
94217
Dog
LDL receptor related protein 1B
VGNC:42774
476136
Opossum
LDL receptor related protein 1B
100017307
Chicken
LDL receptor related protein 1B
CGNC:9423
424301
Species
Name
OMA
EggNOG
Inparanoid
Macaque
LDL receptor related protein 1B
Mouse
Dog
LDL receptor related protein 1B
Opossum
LDL receptor related protein 1B
Chicken
LDL receptor related protein 1B
Publication Statistics
PubMed Score 82.59
PubMed score by year
PubTator Score 38.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title