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Tbio
LRIG2
Leucine-rich repeats and immunoglobulin-like domains protein 2

Protein Summary
Description
This gene encodes a transmembrane protein containing leucine-rich repeats and immunoglobulin-like domains. The encoded protein promotes epidermal growth factor signalling, resulting in increased proliferation. Its expression in the cytoplasm of glioma cells is correlated with poor survival. Mutations in this gene can cause urofacial syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361127
  • ENSP00000355396
  • ENSG00000198799

Symbol
  • KIAA0806
  • LIG2
  • LIG2
  • UFS2
  • LIG-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
histone modification site profile
0.91
transcription factor binding site profile
0.8
transcription factor
0.61
cell line
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.7   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 132   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.7   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 132   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.928620365
p_ni:  0.071379635
Score:  0.838
Data Source:  BioPlex,STRINGDB
PON2
Tbio
Family:  Enzyme
Novelty:  0.00414855
p_int:  0.917612173
p_ni:  0.082387827
Score:  0.653
Data Source:  BioPlex,STRINGDB
RLN1
Tbio
Novelty:  0.03992636
p_int:  0.814978431
p_ni:  0.185021569
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.766274913
p_ni:  0.233725087
Data Source:  BioPlex
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.795
Data Source:  STRINGDB
ADGRL1
Tbio
Family:  GPCR
Novelty:  0.00957739
Score:  0.683
Data Source:  STRINGDB
ADGRL2
Tbio
Family:  GPCR
Novelty:  0.00985539
Score:  0.683
Data Source:  STRINGDB
ADGRL3
Tbio
Family:  GPCR
Novelty:  0.00268343
Score:  0.683
Data Source:  STRINGDB
HPSE2
Tbio
Family:  Enzyme
Novelty:  0.00583615
Score:  0.677
Data Source:  STRINGDB
CNPY4
Tdark
Novelty:  0.59578334
Score:  0.66
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and immunoglobulin like domains 2
104004057
Macaque
leucine rich repeats and immunoglobulin like domains 2
706897
Mouse
MGI:2443718
269473
Rat
RGD:1309554
310753
Dog
leucine rich repeats and immunoglobulin like domains 2
VGNC:42768
483215
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and immunoglobulin like domains 2
Macaque
leucine rich repeats and immunoglobulin like domains 2
Mouse
Rat
Dog
leucine rich repeats and immunoglobulin like domains 2
Publication Statistics
PubMed Score 24.70
PubMed score by year
PubTator Score 22.26
PubTator score by year
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Related Publications
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PMID
Year
Title