Tbio LRIG1 Leucine-rich repeats and immunoglobulin-like domains protein 1

Protein Summary

Description

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.

Uniprot Accession IDs

• Q96JA1
• Q6IQ51
• Q96CF9
• Q9BYB8
• Q9UFI4
• LIG-1

Gene Name

• LRIG1

Ensembl ID

• ENST00000273261
• ENSP00000273261
• ENSG00000144749
• ENST00000383703
• ENSP00000373208
• ENST00000631853
• ENSP00000488729
• ENSG00000282243
• ENST00000633161
• ENSP00000488182

Symbol

• LIG1
• LIG1
• LIG-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
transcription factor perturbation	0.99
PubMedID	0.91
kinase perturbation	0.88
transcription factor binding site profile	0.83

Protein Classes

PANTHER Classes

Protein / Receptor / Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1

Protein / Extracellular Matrix Protein / Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1

DTO Classes

Protein / Receptor / Leucine-rich Repeats And Immunoglobulin-like Domains Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.11   (req: < 5)

Gene RIFs: 78   (req: <= 3)

Antibodies: 209   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 141.11   (req: >= 5)

Gene RIFs: 78   (req: > 3)

Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0