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Tdark
LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

Protein Summary
Description
Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369763
  • ENSP00000358778
  • ENSG00000121931
  • ENST00000485275
  • ENSP00000432290
  • ENST00000494675
  • ENSP00000435259

Symbol
  • C1orf103
  • RIF1
  • RIF1
  • HBiX1
  • C1orf103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.84
hub protein
0.63
transcription factor
0.56
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.2   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.2   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
CARD8
Tbio
Family:  Enzyme
Novelty:  0.0146799
p_int:  0.999953103
p_ni:  0.000046897
Data Source:  BioPlex
PRR20E
Tdark
p_int:  0.999867295
p_ni:  0.000132705
Data Source:  BioPlex
SPINT2
Tbio
Family:  Enzyme
Novelty:  0.0046602
p_int:  0.996821961
p_ni:  0.003178039
Data Source:  BioPlex
CRYBG2
Tdark
Novelty:  0.7500462
p_int:  0.99583561
p_ni:  0.004164305
p_wrong:  8.5e-8
Data Source:  BioPlex
DQX1
Tdark
Family:  Enzyme
Novelty:  1.01984582
p_int:  0.994702615
p_ni:  0.005297385
Score:  0.161
Data Source:  BioPlex,STRINGDB
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.993809623
p_ni:  0.006190377
Data Source:  BioPlex
PSMC3
Tbio
Family:  Enzyme
Novelty:  0.04026019
p_int:  0.993589683
p_ni:  0.006410317
p_wrong:  1e-9
Data Source:  BioPlex
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.987063655
p_ni:  0.012936275
p_wrong:  7e-8
Data Source:  BioPlex
AZIN2
Tbio
Family:  Enzyme
Novelty:  0.00750311
p_int:  0.98618531
p_ni:  0.013814682
p_wrong:  8e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
OLFM2
Tbio
Novelty:  0.06929963
p_int:  0.984658663
p_ni:  0.015341337
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
11.3
eosinophil count
1
1
1
8.6
intraocular pressure measurement
1
1
0
5.7
1.5
1
1
0
1.1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
11.3
eosinophil count
1
8.6
intraocular pressure measurement
0
5.7
1.5
0
1.1
0.3
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ligand dependent nuclear receptor interacting factor 1
VGNC:1302
744971
Macaque
ligand dependent nuclear receptor interacting factor 1
702445
Mouse
MGI:2445214
321000
Rat
RGD:1306520
310775
Dog
ligand dependent nuclear receptor interacting factor 1
VGNC:42766
479906
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ligand dependent nuclear receptor interacting factor 1
Macaque
ligand dependent nuclear receptor interacting factor 1
Mouse
Rat
Dog
ligand dependent nuclear receptor interacting factor 1
Publication Statistics
PubMed Score 3.20
PubMed score by year
PubTator Score 2.53
PubTator score by year
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Related Publications
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PMID
Year
Title