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Tdark
LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

Protein Summary
Description
Together with SMCHD1, involved in chromosome X inactivation in females by promoting the compaction of heterochromatin (PubMed:23542155). Also able to repress the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA), possibly through direct recruitment of histone deacetylases (PubMed:17455211).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369763
  • ENSP00000358778
  • ENSG00000121931
  • ENST00000485275
  • ENSP00000432290
  • ENST00000494675
  • ENSP00000435259

Symbol
  • C1orf103
  • RIF1
  • RIF1
  • HBiX1
  • C1orf103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
transcription factor binding site profile
0.84
hub protein
0.63
transcription factor
0.56
cell line
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.7   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.7   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0