Tbio LRFN5 Leucine-rich repeat and fibronectin type-III domain-containing protein 5

Protein Summary

Description

Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons. This gene encodes a protein that belongs to the leucine-rich repeat and fibronectin type III domain-containing family of proteins. A similar protein in mouse, a glycosylated transmembrane protein, is thought to function in presynaptic differentiation. [provided by RefSeq, Sep 2016]

Uniprot Accession IDs

• Q96NI6
• B3KU78
• Q86XL2

Gene Name

• LRFN5

Ensembl ID

• ENST00000298119
• ENSP00000298119
• ENSG00000165379

Symbol

• C14orf146
• SALM5
• SALM5
• FIGLER8
• C14orf146

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
histone modification site profile	0.7
gene perturbation	0.68
transcription factor	0.65
cell line	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 63   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.1   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0