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Tbio
LRFN4
Leucine-rich repeat and fibronectin type-III domain-containing protein 4

Protein Summary
Description
Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000309602
  • ENSP00000312535
  • ENSG00000173621

Symbol
  • SALM3
  • SALM3
  • SALM3.
  • FIGLER6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor
0.77
cell line
0.65
tissue sample
0.64
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.3   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.3   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
PATL1
Tbio
Novelty:  0.10847
p_int:  0.999992474
p_ni:  0.000007525
Score:  0.158
Data Source:  BioPlex,STRINGDB
LNX1
Tbio
Family:  Enzyme
Novelty:  0.01555905
p_int:  0.99998718
p_ni:  0.00001282
Score:  0.236
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999975772
p_ni:  0.000024228
Score:  0.267
Data Source:  BioPlex,STRINGDB
DYNLL1
Tbio
Novelty:  0.00397334
p_int:  0.99989149
p_ni:  0.00010851
Score:  0.196
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999880207
p_ni:  0.000107377
p_wrong:  0.000012416
Score:  0.716
Data Source:  BioPlex,STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.999806548
p_ni:  0.000193452
Data Source:  BioPlex
CAPN6
Tbio
Novelty:  0.04489237
p_int:  0.998968648
p_ni:  0.001031351
Data Source:  BioPlex
ACBD3
Tbio
Novelty:  0.02992688
p_int:  0.997807442
p_ni:  0.002192557
Score:  0.189
Data Source:  BioPlex,STRINGDB
DYNLL2
Tbio
Novelty:  0.11209457
p_int:  0.997454968
p_ni:  0.002545032
Score:  0.217
Data Source:  BioPlex,STRINGDB
LINGO1
Tbio
Novelty:  0.00778085
p_int:  0.997248287
p_ni:  0.002751711
p_wrong:  3e-9
Score:  0.215
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
4
6
92.4
BMI-adjusted waist circumference
2
2
4
90.3
waist circumference
1
1
1
56.2
chronotype measurement
1
1
1
48.5
physical activity measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
92.4
BMI-adjusted waist circumference
4
90.3
waist circumference
1
56.2
chronotype measurement
1
48.5
physical activity measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 4
VGNC:11897
104001230
Mouse
MGI:2385612
225875
Rat
RGD:1585286
688721
Dog
leucine rich repeat and fibronectin type III domain containing 4
VGNC:42763
610605
Horse
leucine rich repeat and fibronectin type III domain containing 4
VGNC:19751
102149129
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 4
Mouse
Rat
Dog
leucine rich repeat and fibronectin type III domain containing 4
Horse
leucine rich repeat and fibronectin type III domain containing 4
Publication Statistics
PubMed Score 10.30
PubMed score by year
PubTator Score 4.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title