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Tdark
LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

Protein Summary
Description
Cell adhesion molecule that mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner. Promotes neurite outgrowth in hippocampal neurons (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246529
  • ENSP00000246529
  • ENSG00000126243
  • ENST00000588831
  • ENSP00000466989

Symbol
  • SALM4
  • SALM4
  • FIGLER1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
histone modification site profile
0.78
small molecule perturbation
0.65
tissue sample
0.58
cell type or tissue
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 76   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.42   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 76   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
DPEP2
Tbio
Family:  Enzyme
Novelty:  0.14691384
p_int:  0.9907516
p_ni:  0.009248398
p_wrong:  2e-9
Score:  0.186
Data Source:  BioPlex,STRINGDB
TMEM106A
Tbio
Novelty:  0.32470607
p_int:  0.963770273
p_ni:  0.036229177
p_wrong:  5.51e-7
Data Source:  BioPlex
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.920798831
p_ni:  0.079201007
p_wrong:  1.62e-7
Score:  0.176
Data Source:  BioPlex,STRINGDB
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.920715422
p_ni:  0.079284578
Data Source:  BioPlex
LRRTM1
Tbio
Novelty:  0.0409182
p_int:  0.919874736
p_ni:  0.080125264
Score:  0.33
Data Source:  BioPlex,STRINGDB
TMPRSS3
Tbio
Family:  Enzyme
Novelty:  0.0268524
p_int:  0.911620812
p_ni:  0.088379188
Score:  0.187
Data Source:  BioPlex,STRINGDB
ST3GAL4
Tbio
Family:  Enzyme
Novelty:  0.00419433
p_int:  0.907313926
p_ni:  0.092686074
Score:  0.547
Data Source:  BioPlex,STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
p_int:  0.90221024
p_ni:  0.097786898
p_wrong:  0.000002863
Data Source:  BioPlex
PTCH1
Tbio
Novelty:  0.00077635
p_int:  0.87599245
p_ni:  0.12400755
Data Source:  BioPlex
HTR3C
Tchem
Family:  IC
Novelty:  0.112097
p_int:  0.874036813
p_ni:  0.125963187
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Synaptic adhesion-like molecules
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.9
78.5
creatinine measurement
1
1
1
66.8
thrombomodulin measurement
1
1
1
64
glomerular filtration rate
1
1
1
62.8
vitamin D measurement
2
1
2
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.9
78.5
creatinine measurement
1
66.8
thrombomodulin measurement
1
64
glomerular filtration rate
1
62.8
vitamin D measurement
2
53.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 3
VGNC:2413
468842
Mouse
MGI:2442512
233067
Rat
RGD:1305567
308495
Dog
leucine rich repeat and fibronectin type III domain containing 3
VGNC:42762
100688169
Horse
leucine rich repeat and fibronectin type III domain containing 3
VGNC:19750
100147099
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeat and fibronectin type III domain containing 3
Mouse
Rat
Dog
leucine rich repeat and fibronectin type III domain containing 3
Horse
leucine rich repeat and fibronectin type III domain containing 3
Publication Statistics
PubMed Score 4.42
PubMed score by year
PubTator Score 1.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title